Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 206695..207455 Replicon chromosome
Accession NZ_CP047544
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10250

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag DXN29_RS00965 Protein ID WP_000533909.1
Coordinates 206970..207455 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag DXN29_RS00960 Protein ID WP_000965886.1
Coordinates 206695..206982 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN29_RS00935 (201990) 201990..202292 + 303 WP_000605590.1 YsaB family lipoprotein -
DXN29_RS00940 (202431) 202431..203342 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
DXN29_RS00945 (203352) 203352..205421 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
DXN29_RS00950 (205603) 205603..205878 + 276 Protein_189 IS3 family transposase -
DXN29_RS00955 (206050) 206050..206517 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
DXN29_RS00960 (206695) 206695..206982 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
DXN29_RS00965 (206970) 206970..207455 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
DXN29_RS00970 (207827) 207827..208366 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
DXN29_RS00975 (208540) 208540..208752 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
DXN29_RS00980 (209041) 209041..209331 - 291 WP_000455790.1 HTH-type transcriptional regulator -
DXN29_RS00985 (209770) 209770..210480 + 711 WP_000190524.1 DUF3053 domain-containing protein -
DXN29_RS00990 (210530) 210530..211504 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
DXN29_RS00995 (211723) 211723..212385 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T146562 WP_000533909.1 NZ_CP047544:206970-207455 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T146562 NZ_CP062761:4494310-4494570 [Escherichia coli O157:H7]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT146562 WP_000965886.1 NZ_CP047544:206695-206982 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT146562 NZ_CP062761:4494031-4494291 [Escherichia coli O157:H7]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References