Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4791635..4792395 Replicon chromosome
Accession NZ_CP047542
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10330

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag DXN30_RS23520 Protein ID WP_000533909.1
Coordinates 4791635..4792120 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag DXN30_RS23525 Protein ID WP_000965886.1
Coordinates 4792108..4792395 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN30_RS23490 (4786705) 4786705..4787367 + 663 WP_000747548.1 OmpA family lipoprotein -
DXN30_RS23495 (4787586) 4787586..4788560 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
DXN30_RS23500 (4788610) 4788610..4789320 - 711 WP_000190524.1 DUF3053 domain-containing protein -
DXN30_RS23505 (4789759) 4789759..4790049 + 291 WP_000455790.1 HTH-type transcriptional regulator -
DXN30_RS23510 (4790338) 4790338..4790550 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
DXN30_RS23515 (4790724) 4790724..4791263 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
DXN30_RS23520 (4791635) 4791635..4792120 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
DXN30_RS23525 (4792108) 4792108..4792395 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
DXN30_RS23530 (4792573) 4792573..4793040 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
DXN30_RS23535 (4793212) 4793212..4793487 - 276 Protein_4589 IS3 family transposase -
DXN30_RS23540 (4793669) 4793669..4795738 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
DXN30_RS23545 (4795748) 4795748..4796659 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
DXN30_RS23550 (4796798) 4796798..4797100 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T146560 WP_000533909.1 NZ_CP047542:c4792120-4791635 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T146560 NZ_CP062761:4192056-4192274 [Escherichia coli O157:H7]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT146560 WP_000965886.1 NZ_CP047542:c4792395-4792108 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT146560 NZ_CP062761:4191656-4192030 [Escherichia coli O157:H7]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACTCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References