Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4128043..4128703 Replicon chromosome
Accession NZ_CP047542
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10330

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag DXN30_RS20260 Protein ID WP_000244756.1
Coordinates 4128043..4128456 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag DXN30_RS20265 Protein ID WP_000351186.1
Coordinates 4128437..4128703 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN30_RS20240 (4123984) 4123984..4125717 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
DXN30_RS20245 (4125723) 4125723..4126436 - 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DXN30_RS20250 (4126460) 4126460..4127356 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
DXN30_RS20255 (4127469) 4127469..4127990 + 522 WP_001055885.1 flavodoxin FldB -
DXN30_RS20260 (4128043) 4128043..4128456 - 414 WP_000244756.1 protein YgfX Toxin
DXN30_RS20265 (4128437) 4128437..4128703 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
DXN30_RS20270 (4128953) 4128953..4129933 + 981 WP_000874172.1 tRNA-modifying protein YgfZ -
DXN30_RS20275 (4130049) 4130049..4130708 - 660 WP_000250289.1 hemolysin III family protein -
DXN30_RS20280 (4130872) 4130872..4131183 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
DXN30_RS20285 (4131342) 4131342..4132775 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T146557 WP_000244756.1 NZ_CP047542:c4128456-4128043 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T146557 NZ_CP062761:c3562707-3562552 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT146557 WP_000351186.1 NZ_CP047542:c4128703-4128437 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT146557 NZ_CP062761:3562719-3562777 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References