Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 516661..517442 Replicon chromosome
Accession NZ_CP047542
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10330

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag DXN30_RS02400 Protein ID WP_000626099.1
Coordinates 516951..517442 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag DXN30_RS02395 Protein ID WP_001110452.1
Coordinates 516661..516954 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN30_RS02365 (512985) 512985..513890 + 906 WP_001268200.1 YjiK family protein -
DXN30_RS02370 (514184) 514184..514453 - 270 WP_010989096.1 hypothetical protein -
DXN30_RS02375 (514461) 514461..514676 - 216 WP_001595136.1 hypothetical protein -
DXN30_RS02380 (514699) 514699..514986 - 288 WP_001269916.1 transcriptional regulator RtsB -
DXN30_RS02385 (514983) 514983..515858 - 876 WP_000921674.1 AraC family transcriptional regulator -
DXN30_RS02390 (516123) 516123..516344 - 222 WP_001576552.1 hypothetical protein -
DXN30_RS02395 (516661) 516661..516954 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
DXN30_RS02400 (516951) 516951..517442 + 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
DXN30_RS02405 (517690) 517690..518442 - 753 WP_000842434.1 non-specific acid phosphatase -
DXN30_RS02410 (518545) 518545..518619 - 75 Protein_452 porin family protein -
DXN30_RS02415 (519652) 519652..520029 - 378 WP_000916345.1 EthD family reductase -
DXN30_RS02420 (520101) 520101..520433 + 333 WP_001165471.1 MerR family transcriptional regulator -
DXN30_RS02425 (520524) 520524..520601 + 78 Protein_455 helix-turn-helix domain-containing protein -
DXN30_RS02430 (520792) 520792..521664 + 873 WP_033567082.1 ParA family protein -
DXN30_RS02435 (521661) 521661..522017 + 357 WP_033567083.1 hypothetical protein -
DXN30_RS02440 (522014) 522014..522256 + 243 WP_197603740.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T146539 WP_000626099.1 NZ_CP047542:516951-517442 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T146539 NZ_CP062759:71598-71756 [Escherichia coli O157:H7]
ATGAAACTACCACGCAGCTCTCTTGTCTGGTGTGTGTTGATAGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGATACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT146539 WP_001110452.1 NZ_CP047542:516661-516954 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT146539 NZ_CP062759:71335-71533 [Escherichia coli O157:H7]
TCACACGGATTGCCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAATGTGGTCAGCGTGCTGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References