Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4454881..4455662 | Replicon | chromosome |
| Accession | NZ_CP047540 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10359 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | DXN31_RS21935 | Protein ID | WP_000626099.1 |
| Coordinates | 4454881..4455372 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | DXN31_RS21940 | Protein ID | WP_001110452.1 |
| Coordinates | 4455369..4455662 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DXN31_RS21895 (4450067) | 4450067..4450309 | - | 243 | WP_197603740.1 | hypothetical protein | - |
| DXN31_RS21900 (4450306) | 4450306..4450662 | - | 357 | WP_033567083.1 | hypothetical protein | - |
| DXN31_RS21905 (4450659) | 4450659..4451531 | - | 873 | WP_033567082.1 | ParA family protein | - |
| DXN31_RS21910 (4451722) | 4451722..4451799 | - | 78 | Protein_4293 | helix-turn-helix domain-containing protein | - |
| DXN31_RS21915 (4451890) | 4451890..4452222 | - | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| DXN31_RS21920 (4452294) | 4452294..4452671 | + | 378 | WP_000916345.1 | EthD family reductase | - |
| DXN31_RS21925 (4453704) | 4453704..4453778 | + | 75 | Protein_4296 | porin family protein | - |
| DXN31_RS21930 (4453881) | 4453881..4454633 | + | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| DXN31_RS21935 (4454881) | 4454881..4455372 | - | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| DXN31_RS21940 (4455369) | 4455369..4455662 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| DXN31_RS21945 (4455979) | 4455979..4456200 | + | 222 | WP_001576552.1 | hypothetical protein | - |
| DXN31_RS21950 (4456465) | 4456465..4457340 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| DXN31_RS21955 (4457337) | 4457337..4457624 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| DXN31_RS21960 (4457647) | 4457647..4457862 | + | 216 | WP_001595136.1 | hypothetical protein | - |
| DXN31_RS21965 (4457870) | 4457870..4458139 | + | 270 | WP_010989096.1 | hypothetical protein | - |
| DXN31_RS21970 (4458433) | 4458433..4459338 | - | 906 | WP_001268200.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T146533 WP_000626099.1 NZ_CP047540:c4455372-4454881 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T146533 NZ_CP062758:c4699711-4699397 [Escherichia coli O157:H7]
ATGCAATTTACGGTATACCGCAGTCGCAGTAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
ATGCAATTTACGGTATACCGCAGTCGCAGTAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT146533 WP_001110452.1 NZ_CP047540:c4455662-4455369 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT146533 NZ_CP062758:c4699947-4699714 [Escherichia coli O157:H7]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 | |
| AlphaFold DB | A0A5I1DGA4 |