146533

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4454881..4455662 Replicon chromosome
Accession NZ_CP047540
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10359

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag DXN31_RS21935 Protein ID WP_000626099.1
Coordinates 4454881..4455372 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag DXN31_RS21940 Protein ID WP_001110452.1
Coordinates 4455369..4455662 (-) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN31_RS21895 (4450067) 4450067..4450309 - 243 WP_197603740.1 hypothetical protein -
DXN31_RS21900 (4450306) 4450306..4450662 - 357 WP_033567083.1 hypothetical protein -
DXN31_RS21905 (4450659) 4450659..4451531 - 873 WP_033567082.1 ParA family protein -
DXN31_RS21910 (4451722) 4451722..4451799 - 78 Protein_4293 helix-turn-helix domain-containing protein -
DXN31_RS21915 (4451890) 4451890..4452222 - 333 WP_001165471.1 MerR family transcriptional regulator -
DXN31_RS21920 (4452294) 4452294..4452671 + 378 WP_000916345.1 EthD family reductase -
DXN31_RS21925 (4453704) 4453704..4453778 + 75 Protein_4296 porin family protein -
DXN31_RS21930 (4453881) 4453881..4454633 + 753 WP_000842434.1 non-specific acid phosphatase -
DXN31_RS21935 (4454881) 4454881..4455372 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
DXN31_RS21940 (4455369) 4455369..4455662 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
DXN31_RS21945 (4455979) 4455979..4456200 + 222 WP_001576552.1 hypothetical protein -
DXN31_RS21950 (4456465) 4456465..4457340 + 876 WP_000921674.1 AraC family transcriptional regulator -
DXN31_RS21955 (4457337) 4457337..4457624 + 288 WP_001269916.1 transcriptional regulator RtsB -
DXN31_RS21960 (4457647) 4457647..4457862 + 216 WP_001595136.1 hypothetical protein -
DXN31_RS21965 (4457870) 4457870..4458139 + 270 WP_010989096.1 hypothetical protein -
DXN31_RS21970 (4458433) 4458433..4459338 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(85-145)

Antitoxin

(14-88)


Sequences


Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T146533 WP_000626099.1 NZ_CP047540:c4455372-4454881 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T146533 NZ_CP062758:c4699711-4699397 [Escherichia coli O157:H7]
ATGCAATTTACGGTATACCGCAGTCGCAGTAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT146533 WP_001110452.1 NZ_CP047540:c4455662-4455369 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT146533 NZ_CP062758:c4699947-4699714 [Escherichia coli O157:H7]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7AK7


Antitoxin

Source ID Structure
AlphaFold DB A0A5I1DGA4

References