Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4244803..4245319 Replicon chromosome
Accession NZ_CP047540
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10359

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag DXN31_RS20830 Protein ID WP_000220578.1
Coordinates 4244803..4245087 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag DXN31_RS20835 Protein ID WP_000212724.1
Coordinates 4245077..4245319 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN31_RS20815 (4240015) 4240015..4241667 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
DXN31_RS20820 (4242076) 4242076..4244214 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
DXN31_RS20825 (4244335) 4244335..4244799 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DXN31_RS20830 (4244803) 4244803..4245087 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DXN31_RS20835 (4245077) 4245077..4245319 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DXN31_RS20840 (4245397) 4245397..4247310 - 1914 WP_001212137.1 BglG family transcription antiterminator -
DXN31_RS20845 (4247327) 4247327..4248067 - 741 WP_000779263.1 KDGP aldolase family protein -
DXN31_RS20850 (4248064) 4248064..4249182 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
DXN31_RS20855 (4249166) 4249166..4250299 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T146532 WP_000220578.1 NZ_CP047540:c4245087-4244803 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T146532 NZ_CP062758:4468001-4468261 [Escherichia coli O157:H7]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT146532 WP_000212724.1 NZ_CP047540:c4245319-4245077 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT146532 NZ_CP062758:4467722-4467982 [Escherichia coli O157:H7]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References