Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3508018..3508638 Replicon chromosome
Accession NZ_CP047540
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10359

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag DXN31_RS17335 Protein ID WP_001280991.1
Coordinates 3508420..3508638 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag DXN31_RS17330 Protein ID WP_000344807.1
Coordinates 3508018..3508392 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN31_RS17320 (3503157) 3503157..3504350 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DXN31_RS17325 (3504373) 3504373..3507522 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
DXN31_RS17330 (3508018) 3508018..3508392 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
DXN31_RS17335 (3508420) 3508420..3508638 + 219 WP_001280991.1 HHA domain-containing protein Toxin
DXN31_RS17340 (3508817) 3508817..3509368 + 552 WP_001278792.1 maltose O-acetyltransferase -
DXN31_RS17345 (3509485) 3509485..3509955 + 471 WP_000136181.1 YlaC family protein -
DXN31_RS17350 (3510011) 3510011..3510151 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
DXN31_RS17355 (3510157) 3510157..3510417 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
DXN31_RS17360 (3510642) 3510642..3512192 + 1551 WP_000213139.1 EAL domain-containing protein -
DXN31_RS17370 (3512423) 3512423..3512812 + 390 WP_000961285.1 MGMT family protein -
DXN31_RS17375 (3512845) 3512845..3513414 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T146527 WP_001280991.1 NZ_CP047540:3508420-3508638 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T146527 NZ_CP062758:c3575162-3575007 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT146527 WP_000344807.1 NZ_CP047540:3508018-3508392 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT146527 NZ_CP062758:3575174-3575232 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References