Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3508018..3508638 | Replicon | chromosome |
Accession | NZ_CP047540 | ||
Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10359 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | V1H8E6 |
Locus tag | DXN31_RS17335 | Protein ID | WP_001280991.1 |
Coordinates | 3508420..3508638 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | V1H4V6 |
Locus tag | DXN31_RS17330 | Protein ID | WP_000344807.1 |
Coordinates | 3508018..3508392 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DXN31_RS17320 (3503157) | 3503157..3504350 | + | 1194 | WP_001039202.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
DXN31_RS17325 (3504373) | 3504373..3507522 | + | 3150 | WP_001132508.1 | efflux RND transporter permease AcrB | - |
DXN31_RS17330 (3508018) | 3508018..3508392 | + | 375 | WP_000344807.1 | Hha toxicity modulator TomB | Antitoxin |
DXN31_RS17335 (3508420) | 3508420..3508638 | + | 219 | WP_001280991.1 | HHA domain-containing protein | Toxin |
DXN31_RS17340 (3508817) | 3508817..3509368 | + | 552 | WP_001278792.1 | maltose O-acetyltransferase | - |
DXN31_RS17345 (3509485) | 3509485..3509955 | + | 471 | WP_000136181.1 | YlaC family protein | - |
DXN31_RS17350 (3510011) | 3510011..3510151 | - | 141 | WP_001197749.1 | type B 50S ribosomal protein L36 | - |
DXN31_RS17355 (3510157) | 3510157..3510417 | - | 261 | WP_000801415.1 | type B 50S ribosomal protein L31 | - |
DXN31_RS17360 (3510642) | 3510642..3512192 | + | 1551 | WP_000213139.1 | EAL domain-containing protein | - |
DXN31_RS17370 (3512423) | 3512423..3512812 | + | 390 | WP_000961285.1 | MGMT family protein | - |
DXN31_RS17375 (3512845) | 3512845..3513414 | - | 570 | WP_000779803.1 | YbaY family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8613.97 Da Isoelectric Point: 8.9008
>T146527 WP_001280991.1 NZ_CP047540:3508420-3508638 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T146527 NZ_CP062758:c3575162-3575007 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14453.27 Da Isoelectric Point: 5.1444
>AT146527 WP_000344807.1 NZ_CP047540:3508018-3508392 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
Download Length: 375 bp
>AT146527 NZ_CP062758:3575174-3575232 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|