Detailed information of TA system TA146526

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 2460061..2460583
• Replicon: chromosome
• Accession: NZ_CP047540
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10359

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: B5F5Y5
• Locus tag: DXN31_RS12070
• Protein ID: WP_000221343.1
• Coordinates: 2460299..2460583 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: DXN31_RS12065
• Protein ID: WP_000885424.1
• Coordinates: 2460061..2460309 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DXN31_RS12040 (2455277)	2455277..2456743	+	1467	WP_000987828.1	hypothetical protein	-
DXN31_RS12045 (2457551)	2457551..2458265	+	715	Protein_2363	helix-turn-helix domain-containing protein	-
DXN31_RS12050 (2458321)	2458321..2459229	-	909	WP_010989018.1	hypothetical protein	-
DXN31_RS12055 (2459372)	2459372..2459704	-	333	WP_000253154.1	DUF1493 family protein	-
DXN31_RS12060 (2459694)	2459694..2459909	-	216	WP_000206207.1	hypothetical protein	-
DXN31_RS12065 (2460061)	2460061..2460309	+	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DXN31_RS12070 (2460299)	2460299..2460583	+	285	WP_000221343.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DXN31_RS12075 (2460754)	2460754..2461143	+	390	WP_000194089.1	RidA family protein	-
DXN31_RS12080 (2461195)	2461195..2462274	-	1080	WP_000954688.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
DXN31_RS12085 (2462467)	2462467..2462955	-	489	WP_001293638.1	MarR family winged helix-turn-helix transcriptional regulator	-
DXN31_RS12090 (2463000)	2463000..2464508	+	1509	WP_000199411.1	FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11075.85 Da
• Isoelectric Point: 10.6500

>T146526 WP_000221343.1 NZ_CP047540:2460299-2460583 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Nucleotide

• Length: 285 bp

>T146526 NZ_CP062758:c3356473-3356099 [Escherichia coli O157:H7]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT146526 WP_000885424.1 NZ_CP047540:2460061-2460309 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT146526 NZ_CP062758:c3356894-3356520 [Escherichia coli O157:H7]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Structures

Toxin

• AlphaFold DB: A0A5H5JSW4

Antitoxin

• AlphaFold DB: A0A5I0WPN5