Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870106..870766 Replicon chromosome
Accession NZ_CP047540
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10359

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag DXN31_RS04220 Protein ID WP_000244756.1
Coordinates 870353..870766 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag DXN31_RS04215 Protein ID WP_000351186.1
Coordinates 870106..870372 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN31_RS04195 (866034) 866034..867467 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
DXN31_RS04200 (867626) 867626..867937 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
DXN31_RS04205 (868101) 868101..868760 + 660 WP_000250289.1 hemolysin III family protein -
DXN31_RS04210 (868876) 868876..869856 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
DXN31_RS04215 (870106) 870106..870372 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
DXN31_RS04220 (870353) 870353..870766 + 414 WP_000244756.1 protein YgfX Toxin
DXN31_RS04225 (870819) 870819..871340 - 522 WP_001055885.1 flavodoxin FldB -
DXN31_RS04230 (871453) 871453..872349 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
DXN31_RS04235 (872373) 872373..873086 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DXN31_RS04240 (873092) 873092..874825 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T146515 WP_000244756.1 NZ_CP047540:870353-870766 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T146515 NZ_CP062758:c450818-450333 [Escherichia coli O157:H7]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT146515 WP_000351186.1 NZ_CP047540:870106-870372 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT146515 NZ_CP062758:c451087-450809 [Escherichia coli O157:H7]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGCCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References