Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 18692..19239 Replicon plasmid unnamedB
Accession NZ_CP047539
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10405

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag DXN32_RS25920 Protein ID WP_001384452.1
Coordinates 18961..19239 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0S0ZPX5
Locus tag DXN32_RS25915 Protein ID WP_032291093.1
Coordinates 18692..18961 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN32_RS25890 (14335) 14335..14868 - 534 WP_001372168.1 transcription termination/antitermination NusG family protein -
DXN32_RS25895 (15310) 15310..15597 - 288 WP_000074855.1 conjugal transfer protein TraA -
DXN32_RS25900 (15635) 15635..15793 - 159 Protein_18 ash family protein -
DXN32_RS25905 (16750) 16750..17781 + 1032 WP_023518831.1 plasmid replication initiator RepA -
DXN32_RS25910 (18479) 18479..18637 + 159 WP_038349023.1 hypothetical protein -
DXN32_RS25915 (18692) 18692..18961 + 270 WP_032291093.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
DXN32_RS25920 (18961) 18961..19239 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
DXN32_RS25925 (19279) 19279..20127 + 849 WP_032291092.1 3'-5' exonuclease -
DXN32_RS25930 (20443) 20443..20952 - 510 WP_032291091.1 hypothetical protein -
DXN32_RS25935 (21008) 21008..21610 - 603 WP_000517687.1 ProQ/FINO family protein -
DXN32_RS25940 (21963) 21963..23308 + 1346 Protein_26 protein YagA -
DXN32_RS25945 (23859) 23859..24161 - 303 WP_001245884.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-14 - 1..88993 88993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T146507 WP_001384452.1 NZ_CP047539:18961-19239 [Salmonella enterica subsp. enterica serovar Typhimurium]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

>T146507 NZ_CP062756:2066-2341 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10069.43 Da        Isoelectric Point: 8.0565

>AT146507 WP_032291093.1 NZ_CP047539:18692-18961 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLGCGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT146507 NZ_CP062756:1782-2066 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A0S0ZPX5

References