Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 68748..70371 Replicon plasmid unnamedA
Accession NZ_CP047538
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10405

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag DXN32_RS24475 Protein ID WP_000088046.1
Coordinates 68748..70073 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag DXN32_RS24480 Protein ID WP_024136327.1
Coordinates 70078..70371 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN32_RS24445 (DXN32_024385) 65418..65717 - 300 WP_001572440.1 hypothetical protein -
DXN32_RS24450 (DXN32_024390) 65772..66008 - 237 Protein_74 type I restriction-modification system subunit M N-terminal domain-containing protein -
DXN32_RS24455 (DXN32_024395) 66462..66887 - 426 WP_001043843.1 hypothetical protein -
DXN32_RS24460 (DXN32_024400) 67141..67956 - 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
DXN32_RS24465 (DXN32_024405) 67969..68379 - 411 WP_000985911.1 hypothetical protein -
DXN32_RS24470 (DXN32_024410) 68481..68687 - 207 WP_000134171.1 hypothetical protein -
DXN32_RS24475 (DXN32_024415) 68748..70073 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
DXN32_RS24480 (DXN32_024420) 70078..70371 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
DXN32_RS24485 (DXN32_024425) 70975..71367 - 393 WP_000341066.1 hypothetical protein -
DXN32_RS24490 (DXN32_024430) 71740..72081 + 342 WP_001151575.1 hypothetical protein -
DXN32_RS24495 (DXN32_024435) 72173..72364 + 192 WP_000398480.1 hypothetical protein -
DXN32_RS24500 (DXN32_024440) 72414..72695 + 282 WP_000077926.1 hypothetical protein -
DXN32_RS26380 73036..73167 - 132 WP_000374059.1 hypothetical protein -
DXN32_RS24505 (DXN32_024445) 73258..74499 - 1242 WP_001053338.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul3 / ant(3'')-Ia / cmlA1 / aadA2 / floR / sul2 / aph(4)-Ia / aac(3)-IVa / aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / qacE / sul1 / oqxB / oqxA sifA / csgG / csgF / csgE / csgD / csgB / csgA / csgC / flgB / flgC / flgE / flgF / flgG / flgH / flgI / flmH 1..329730 329730


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T146506 WP_000088046.1 NZ_CP047538:c70073-68748 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T146506 NZ_CP062755:c5057821-5057648 [Escherichia coli O157:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT146506 WP_024136327.1 NZ_CP047538:c70371-70078 [Salmonella enterica subsp. enterica serovar Typhimurium]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT146506 NZ_CP062755:c5058145-5057849 [Escherichia coli O157:H7]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References