Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3889679..3890493 Replicon chromosome
Accession NZ_CP047537
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10405

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag DXN32_RS19145 Protein ID WP_000971655.1
Coordinates 3889966..3890493 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag DXN32_RS19140 Protein ID WP_000855692.1
Coordinates 3889679..3889969 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN32_RS19110 (3885629) 3885629..3886279 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
DXN32_RS19115 (3886736) 3886736..3887179 + 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
DXN32_RS19120 (3887610) 3887610..3888059 + 450 WP_000381610.1 membrane protein -
DXN32_RS19125 (3888044) 3888044..3888391 + 348 WP_001669174.1 DUF1493 family protein -
DXN32_RS19130 (3888664) 3888664..3888990 - 327 WP_000393302.1 hypothetical protein -
DXN32_RS19135 (3889231) 3889231..3889409 + 179 Protein_3726 IS3 family transposase -
DXN32_RS19140 (3889679) 3889679..3889969 + 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
DXN32_RS19145 (3889966) 3889966..3890493 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
DXN32_RS19150 (3890566) 3890566..3890679 - 114 Protein_3729 IS5/IS1182 family transposase -
DXN32_RS19155 (3890679) 3890679..3891104 - 426 Protein_3730 cytoplasmic protein -
DXN32_RS19160 (3891263) 3891263..3893830 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -
DXN32_RS19165 (3893886) 3893886..3894266 - 381 WP_001070479.1 DUF4440 domain-containing protein -
DXN32_RS19170 (3894263) 3894263..3895471 - 1209 WP_000222406.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T146500 WP_000971655.1 NZ_CP047537:3889966-3890493 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T146500 NZ_CP062755:4215366-4215584 [Escherichia coli O157:H7]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT146500 WP_000855692.1 NZ_CP047537:3889679-3889969 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT146500 NZ_CP062755:4214966-4215340 [Escherichia coli O157:H7]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACTCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References