Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2432727..2433249 Replicon chromosome
Accession NZ_CP047537
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10405

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag DXN32_RS11885 Protein ID WP_000221343.1
Coordinates 2432727..2433011 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag DXN32_RS11890 Protein ID WP_000885424.1
Coordinates 2433001..2433249 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN32_RS11865 (2428802) 2428802..2430310 - 1509 WP_000199411.1 FAD-dependent oxidoreductase -
DXN32_RS11870 (2430355) 2430355..2430843 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
DXN32_RS11875 (2431036) 2431036..2432115 + 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
DXN32_RS11880 (2432167) 2432167..2432556 - 390 WP_000194089.1 RidA family protein -
DXN32_RS11885 (2432727) 2432727..2433011 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DXN32_RS11890 (2433001) 2433001..2433249 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DXN32_RS11895 (2433401) 2433401..2433616 + 216 WP_000206207.1 hypothetical protein -
DXN32_RS11900 (2433606) 2433606..2433938 + 333 WP_000253154.1 DUF1493 family protein -
DXN32_RS11905 (2434081) 2434081..2434989 + 909 WP_010989018.1 hypothetical protein -
DXN32_RS11910 (2435045) 2435045..2435759 - 715 Protein_2311 helix-turn-helix domain-containing protein -
DXN32_RS11915 (2436567) 2436567..2438033 - 1467 WP_000987828.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T146491 WP_000221343.1 NZ_CP047537:c2433011-2432727 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T146491 NZ_CP062755:c2462788-2462633 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT146491 WP_000885424.1 NZ_CP047537:c2433249-2433001 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT146491 NZ_CP062755:2462800-2462858 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References