Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1465366..1465986 Replicon chromosome
Accession NZ_CP047537
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10405

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag DXN32_RS07015 Protein ID WP_001280991.1
Coordinates 1465366..1465584 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag DXN32_RS07020 Protein ID WP_000344807.1
Coordinates 1465612..1465986 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN32_RS06975 (1460590) 1460590..1461159 + 570 WP_000779803.1 YbaY family lipoprotein -
DXN32_RS06980 (1461192) 1461192..1461581 - 390 WP_000961285.1 MGMT family protein -
DXN32_RS06990 (1461812) 1461812..1463362 - 1551 WP_000213139.1 EAL domain-containing protein -
DXN32_RS06995 (1463587) 1463587..1463847 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
DXN32_RS07000 (1463853) 1463853..1463993 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
DXN32_RS07005 (1464049) 1464049..1464519 - 471 WP_000136181.1 YlaC family protein -
DXN32_RS07010 (1464636) 1464636..1465187 - 552 WP_001278792.1 maltose O-acetyltransferase -
DXN32_RS07015 (1465366) 1465366..1465584 - 219 WP_001280991.1 HHA domain-containing protein Toxin
DXN32_RS07020 (1465612) 1465612..1465986 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
DXN32_RS07025 (1466482) 1466482..1469631 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
DXN32_RS07030 (1469654) 1469654..1470847 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T146490 WP_001280991.1 NZ_CP047537:c1465584-1465366 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T146490 NZ_CP062755:2254729-2254905 [Escherichia coli O157:H7]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT146490 WP_000344807.1 NZ_CP047537:c1465986-1465612 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT146490 NZ_CP062755:2254951-2255367 [Escherichia coli O157:H7]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCAGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References