Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4262754..4263535 Replicon chromosome
Accession NZ_CP047535
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10452

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag DXN08_RS21045 Protein ID WP_000626099.1
Coordinates 4262754..4263245 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag DXN08_RS21050 Protein ID WP_001110452.1
Coordinates 4263242..4263535 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN08_RS21005 (4257940) 4257940..4258182 - 243 WP_197603740.1 hypothetical protein -
DXN08_RS21010 (4258179) 4258179..4258535 - 357 WP_033567083.1 hypothetical protein -
DXN08_RS21015 (4258532) 4258532..4259404 - 873 WP_033567082.1 ParA family protein -
DXN08_RS21020 (4259595) 4259595..4259672 - 78 Protein_4114 helix-turn-helix domain-containing protein -
DXN08_RS21025 (4259763) 4259763..4260095 - 333 WP_001165471.1 MerR family transcriptional regulator -
DXN08_RS21030 (4260167) 4260167..4260544 + 378 WP_000916345.1 EthD family reductase -
DXN08_RS21035 (4261577) 4261577..4261651 + 75 Protein_4117 porin family protein -
DXN08_RS21040 (4261754) 4261754..4262506 + 753 WP_000842434.1 non-specific acid phosphatase -
DXN08_RS21045 (4262754) 4262754..4263245 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
DXN08_RS21050 (4263242) 4263242..4263535 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
DXN08_RS21055 (4263852) 4263852..4264073 + 222 WP_001576552.1 hypothetical protein -
DXN08_RS21060 (4264338) 4264338..4265213 + 876 WP_000921674.1 AraC family transcriptional regulator -
DXN08_RS21065 (4265210) 4265210..4265497 + 288 WP_001269916.1 transcriptional regulator RtsB -
DXN08_RS21070 (4265520) 4265520..4265735 + 216 WP_001595136.1 hypothetical protein -
DXN08_RS21075 (4265743) 4265743..4266012 + 270 WP_010989096.1 hypothetical protein -
DXN08_RS21080 (4266306) 4266306..4267211 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T146478 WP_000626099.1 NZ_CP047535:c4263245-4262754 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T146478 NZ_CP062753:51522-51827 [Escherichia coli O157:H7]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT146478 WP_001110452.1 NZ_CP047535:c4263535-4263242 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT146478 NZ_CP062753:51302-51520 [Escherichia coli O157:H7]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References