Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3315892..3316512 Replicon chromosome
Accession NZ_CP047535
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10452

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag DXN08_RS16445 Protein ID WP_001280991.1
Coordinates 3316294..3316512 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag DXN08_RS16440 Protein ID WP_000344807.1
Coordinates 3315892..3316266 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN08_RS16430 (3311031) 3311031..3312224 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DXN08_RS16435 (3312247) 3312247..3315396 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
DXN08_RS16440 (3315892) 3315892..3316266 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
DXN08_RS16445 (3316294) 3316294..3316512 + 219 WP_001280991.1 HHA domain-containing protein Toxin
DXN08_RS16450 (3316691) 3316691..3317242 + 552 WP_001278792.1 maltose O-acetyltransferase -
DXN08_RS16455 (3317359) 3317359..3317829 + 471 WP_000136181.1 YlaC family protein -
DXN08_RS16460 (3317885) 3317885..3318025 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
DXN08_RS16465 (3318031) 3318031..3318291 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
DXN08_RS16470 (3318516) 3318516..3320066 + 1551 WP_000213139.1 EAL domain-containing protein -
DXN08_RS16480 (3320297) 3320297..3320686 + 390 WP_000961285.1 MGMT family protein -
DXN08_RS16485 (3320719) 3320719..3321288 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T146472 WP_001280991.1 NZ_CP047535:3316294-3316512 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T146472 NZ_CP062752:4465756-4466016 [Escherichia coli O157:H7]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT146472 WP_000344807.1 NZ_CP047535:3315892-3316266 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT146472 NZ_CP062752:4465477-4465737 [Escherichia coli O157:H7]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References