Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 6358..7118 Replicon chromosome
Accession NZ_CP047535
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10452

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag DXN08_RS00040 Protein ID WP_000533909.1
Coordinates 6633..7118 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag DXN08_RS00035 Protein ID WP_000965886.1
Coordinates 6358..6645 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN08_RS00010 (1653) 1653..1955 + 303 WP_000605590.1 YsaB family lipoprotein -
DXN08_RS00015 (2094) 2094..3005 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
DXN08_RS00020 (3015) 3015..5084 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
DXN08_RS00025 (5266) 5266..5541 + 276 Protein_4 IS3 family transposase -
DXN08_RS00030 (5713) 5713..6180 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
DXN08_RS00035 (6358) 6358..6645 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
DXN08_RS00040 (6633) 6633..7118 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
DXN08_RS00045 (7490) 7490..8029 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
DXN08_RS00050 (8203) 8203..8415 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
DXN08_RS00055 (8704) 8704..8994 - 291 WP_000455790.1 HTH-type transcriptional regulator -
DXN08_RS00060 (9433) 9433..10143 + 711 WP_000190524.1 DUF3053 domain-containing protein -
DXN08_RS00065 (10193) 10193..11167 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
DXN08_RS00070 (11386) 11386..12048 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T146457 WP_000533909.1 NZ_CP047535:6633-7118 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T146457 NZ_CP062752:838170-838634 [Escherichia coli O157:H7]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT146457 WP_000965886.1 NZ_CP047535:6358-6645 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT146457 NZ_CP062752:837835-838170 [Escherichia coli O157:H7]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAGCAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATACAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References