146453

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4471097..4471878 Replicon chromosome
Accession NZ_CP047531
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10484

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag DXN09_RS22005 Protein ID WP_000626099.1
Coordinates 4471097..4471588 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag DXN09_RS22010 Protein ID WP_001110452.1
Coordinates 4471585..4471878 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN09_RS21965 (4466283) 4466283..4466525 - 243 WP_197603740.1 hypothetical protein -
DXN09_RS21970 (4466522) 4466522..4466878 - 357 WP_033567083.1 hypothetical protein -
DXN09_RS21975 (4466875) 4466875..4467747 - 873 WP_033567082.1 ParA family protein -
DXN09_RS21980 (4467938) 4467938..4468015 - 78 Protein_4307 helix-turn-helix domain-containing protein -
DXN09_RS21985 (4468106) 4468106..4468438 - 333 WP_001165471.1 MerR family transcriptional regulator -
DXN09_RS21990 (4468510) 4468510..4468887 + 378 WP_000916345.1 EthD family reductase -
DXN09_RS21995 (4469920) 4469920..4469994 + 75 Protein_4310 porin family protein -
DXN09_RS22000 (4470097) 4470097..4470849 + 753 WP_000842434.1 non-specific acid phosphatase -
DXN09_RS22005 (4471097) 4471097..4471588 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
DXN09_RS22010 (4471585) 4471585..4471878 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
DXN09_RS22015 (4472195) 4472195..4472416 + 222 WP_001576552.1 hypothetical protein -
DXN09_RS22020 (4472681) 4472681..4473556 + 876 WP_000921674.1 AraC family transcriptional regulator -
DXN09_RS22025 (4473553) 4473553..4473840 + 288 WP_001269916.1 transcriptional regulator RtsB -
DXN09_RS22030 (4473863) 4473863..4474078 + 216 WP_001595136.1 hypothetical protein -
DXN09_RS22035 (4474086) 4474086..4474355 + 270 WP_010989096.1 hypothetical protein -
DXN09_RS22040 (4474649) 4474649..4475554 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T146453 WP_000626099.1 NZ_CP047531:c4471588-4471097 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T146453 NZ_CP062752:408069-408596 [Escherichia coli O157:H7]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCTTTAGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT146453 WP_001110452.1 NZ_CP047531:c4471878-4471585 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT146453 NZ_CP062752:407796-408062 [Escherichia coli O157:H7]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References