Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4261019..4261535 Replicon chromosome
Accession NZ_CP047531
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10484

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag DXN09_RS20900 Protein ID WP_000220578.1
Coordinates 4261019..4261303 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag DXN09_RS20905 Protein ID WP_000212724.1
Coordinates 4261293..4261535 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN09_RS20885 (4256231) 4256231..4257883 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
DXN09_RS20890 (4258292) 4258292..4260430 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
DXN09_RS20895 (4260551) 4260551..4261015 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DXN09_RS20900 (4261019) 4261019..4261303 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DXN09_RS20905 (4261293) 4261293..4261535 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DXN09_RS20910 (4261613) 4261613..4263526 - 1914 WP_001212137.1 BglG family transcription antiterminator -
DXN09_RS20915 (4263543) 4263543..4264283 - 741 WP_000779263.1 KDGP aldolase family protein -
DXN09_RS20920 (4264280) 4264280..4265398 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
DXN09_RS20925 (4265382) 4265382..4266515 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T146452 WP_000220578.1 NZ_CP047531:c4261303-4261019 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T146452 NZ_CP062752:365365-365640 [Escherichia coli O157:H7]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGC
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT146452 WP_000212724.1 NZ_CP047531:c4261535-4261293 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT146452 NZ_CP062752:365637-365996 [Escherichia coli O157:H7]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References