Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 66521..68144 Replicon plasmid unnamed
Accession NZ_CP047530
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10640

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag DXN10_RS24665 Protein ID WP_000088046.1
Coordinates 66819..68144 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag DXN10_RS24660 Protein ID WP_024136327.1
Coordinates 66521..66814 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN10_RS24635 (DXN10_024555) 62393..63634 + 1242 WP_001053338.1 VWA domain-containing protein -
DXN10_RS25405 63725..63856 + 132 WP_000374059.1 hypothetical protein -
DXN10_RS24640 (DXN10_024560) 64197..64478 - 282 WP_000077926.1 hypothetical protein -
DXN10_RS24645 (DXN10_024565) 64528..64719 - 192 WP_000398480.1 hypothetical protein -
DXN10_RS24650 (DXN10_024570) 64811..65152 - 342 WP_001151575.1 hypothetical protein -
DXN10_RS24655 (DXN10_024575) 65525..65917 + 393 WP_000341066.1 hypothetical protein -
DXN10_RS24660 (DXN10_024580) 66521..66814 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
DXN10_RS24665 (DXN10_024585) 66819..68144 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
DXN10_RS24670 (DXN10_024590) 68205..68411 + 207 WP_000134171.1 hypothetical protein -
DXN10_RS24675 (DXN10_024595) 68513..68923 + 411 WP_000985911.1 hypothetical protein -
DXN10_RS24680 (DXN10_024600) 68936..69751 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
DXN10_RS24685 (DXN10_024605) 70005..70430 + 426 WP_001043843.1 hypothetical protein -
DXN10_RS24690 (DXN10_024610) 70884..71119 + 236 Protein_73 type I restriction-modification system subunit M N-terminal domain-containing protein -
DXN10_RS24695 (DXN10_024615) 71174..71473 + 300 WP_001572440.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / aac(3)-IVa / aph(4)-Ia / sul2 / floR / aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aph(3')-Ia / dfrA12 / oqxA / oqxB - 1..197840 197840


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T146431 WP_000088046.1 NZ_CP047530:66819-68144 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T146431 NZ_CP062749:2645973-2646128 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT146431 WP_024136327.1 NZ_CP047530:66521-66814 [Salmonella enterica subsp. enterica serovar Typhimurium]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT146431 NZ_CP062749:c2645961-2645903 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References