146430

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4770955..4771715 Replicon chromosome
Accession NZ_CP047529
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10640

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag DXN10_RS23375 Protein ID WP_000533909.1
Coordinates 4770955..4771440 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag DXN10_RS23380 Protein ID WP_000965886.1
Coordinates 4771428..4771715 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN10_RS23345 (4766025) 4766025..4766687 + 663 WP_000747548.1 OmpA family lipoprotein -
DXN10_RS23350 (4766906) 4766906..4767880 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
DXN10_RS23355 (4767930) 4767930..4768640 - 711 WP_000190524.1 DUF3053 domain-containing protein -
DXN10_RS23360 (4769079) 4769079..4769369 + 291 WP_000455790.1 HTH-type transcriptional regulator -
DXN10_RS23365 (4769658) 4769658..4769870 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
DXN10_RS23370 (4770044) 4770044..4770583 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
DXN10_RS23375 (4770955) 4770955..4771440 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
DXN10_RS23380 (4771428) 4771428..4771715 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
DXN10_RS23385 (4771893) 4771893..4772360 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
DXN10_RS23390 (4772532) 4772532..4772807 - 276 Protein_4559 IS3 family transposase -
DXN10_RS23395 (4772989) 4772989..4775058 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
DXN10_RS23400 (4775068) 4775068..4775979 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
DXN10_RS23405 (4776118) 4776118..4776420 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T146430 WP_000533909.1 NZ_CP047529:c4771440-4770955 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T146430 NZ_CP062749:2315736-2315839 [Escherichia coli O157:H7]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT146430 WP_000965886.1 NZ_CP047529:c4771715-4771428 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT146430 NZ_CP062749:c2315877-2315606 [Escherichia coli O157:H7]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2JDX2

References