146416

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2523717..2524239 Replicon chromosome
Accession NZ_CP047529
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10640

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag DXN10_RS12330 Protein ID WP_000221343.1
Coordinates 2523717..2524001 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag DXN10_RS12335 Protein ID WP_000885424.1
Coordinates 2523991..2524239 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN10_RS12310 (2519792) 2519792..2521300 - 1509 WP_000199411.1 FAD-dependent oxidoreductase -
DXN10_RS12315 (2521345) 2521345..2521833 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
DXN10_RS12320 (2522026) 2522026..2523105 + 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
DXN10_RS12325 (2523157) 2523157..2523546 - 390 WP_000194089.1 RidA family protein -
DXN10_RS12330 (2523717) 2523717..2524001 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DXN10_RS12335 (2523991) 2523991..2524239 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DXN10_RS12340 (2524391) 2524391..2524606 + 216 WP_000206207.1 hypothetical protein -
DXN10_RS12345 (2524596) 2524596..2524928 + 333 WP_000253154.1 DUF1493 family protein -
DXN10_RS12350 (2525071) 2525071..2525979 + 909 WP_010989018.1 hypothetical protein -
DXN10_RS12355 (2526035) 2526035..2526749 - 715 Protein_2396 helix-turn-helix domain-containing protein -
DXN10_RS12360 (2527557) 2527557..2529023 - 1467 WP_000987828.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T146416 WP_000221343.1 NZ_CP047529:c2524001-2523717 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T146416 NZ_CP062746:c5044592-5044419 [Escherichia coli O157:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT146416 WP_000885424.1 NZ_CP047529:c2524239-2523991 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT146416 NZ_CP062746:c5044916-5044620 [Escherichia coli O157:H7]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References