Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1475537..1476157 Replicon chromosome
Accession NZ_CP047529
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10640

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag DXN10_RS07060 Protein ID WP_001280991.1
Coordinates 1475537..1475755 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag DXN10_RS07065 Protein ID WP_000344807.1
Coordinates 1475783..1476157 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN10_RS07020 (1470761) 1470761..1471330 + 570 WP_000779803.1 YbaY family lipoprotein -
DXN10_RS07025 (1471363) 1471363..1471752 - 390 WP_000961285.1 MGMT family protein -
DXN10_RS07035 (1471983) 1471983..1473533 - 1551 WP_000213139.1 EAL domain-containing protein -
DXN10_RS07040 (1473758) 1473758..1474018 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
DXN10_RS07045 (1474024) 1474024..1474164 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
DXN10_RS07050 (1474220) 1474220..1474690 - 471 WP_000136181.1 YlaC family protein -
DXN10_RS07055 (1474807) 1474807..1475358 - 552 WP_001278792.1 maltose O-acetyltransferase -
DXN10_RS07060 (1475537) 1475537..1475755 - 219 WP_001280991.1 HHA domain-containing protein Toxin
DXN10_RS07065 (1475783) 1475783..1476157 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
DXN10_RS07070 (1476653) 1476653..1479802 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
DXN10_RS07075 (1479825) 1479825..1481018 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T146415 WP_001280991.1 NZ_CP047529:c1475755-1475537 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T146415 NZ_CP062746:c4947778-4947428 [Escherichia coli O157:H7]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT146415 WP_000344807.1 NZ_CP047529:c1476157-1475783 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT146415 NZ_CP062746:c4948023-4947772 [Escherichia coli O157:H7]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGTGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References