Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 4791606..4792366 | Replicon | chromosome |
Accession | NZ_CP047527 | ||
Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10648 |
Toxin (Protein)
Gene name | tacT | Uniprot ID | Q57IH1 |
Locus tag | DXN11_RS23510 | Protein ID | WP_000533909.1 |
Coordinates | 4791606..4792091 (-) | Length | 162 a.a. |
Antitoxin (Protein)
Gene name | tacA | Uniprot ID | M7RHS4 |
Locus tag | DXN11_RS23515 | Protein ID | WP_000965886.1 |
Coordinates | 4792079..4792366 (-) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DXN11_RS23480 (4786676) | 4786676..4787338 | + | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
DXN11_RS23485 (4787557) | 4787557..4788531 | + | 975 | WP_000804674.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
DXN11_RS23490 (4788581) | 4788581..4789291 | - | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
DXN11_RS23495 (4789730) | 4789730..4790020 | + | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
DXN11_RS23500 (4790309) | 4790309..4790521 | + | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
DXN11_RS23505 (4790695) | 4790695..4791234 | + | 540 | WP_000047149.1 | copper-binding periplasmic metallochaperone CueP | - |
DXN11_RS23510 (4791606) | 4791606..4792091 | - | 486 | WP_000533909.1 | GNAT family N-acetyltransferase | Toxin |
DXN11_RS23515 (4792079) | 4792079..4792366 | - | 288 | WP_000965886.1 | DUF1778 domain-containing protein | Antitoxin |
DXN11_RS23520 (4792544) | 4792544..4793011 | - | 468 | WP_000702452.1 | GNAT family N-acetyltransferase | - |
DXN11_RS23525 (4793183) | 4793183..4793458 | - | 276 | Protein_4587 | IS3 family transposase | - |
DXN11_RS23530 (4793640) | 4793640..4795709 | - | 2070 | WP_001291736.1 | glycine--tRNA ligase subunit beta | - |
DXN11_RS23535 (4795719) | 4795719..4796630 | - | 912 | WP_001168551.1 | glycine--tRNA ligase subunit alpha | - |
DXN11_RS23540 (4796769) | 4796769..4797071 | - | 303 | WP_000605590.1 | YsaB family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17703.41 Da Isoelectric Point: 9.8719
>T146405 WP_000533909.1 NZ_CP047527:c4792091-4791606 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
>T146405 NZ_CP062746:c3062858-3062703 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10950.60 Da Isoelectric Point: 4.6811
>AT146405 WP_000965886.1 NZ_CP047527:c4792366-4792079 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
Download Length: 288 bp
>AT146405 NZ_CP062746:3062870-3062928 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 7F36 | |
PDB | 7AK8 | |
PDB | 5FVJ |
Antitoxin
Source | ID | Structure |
---|---|---|
PDB | 7AK8 | |
AlphaFold DB | A0A3V2JDX2 |