146405

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4791606..4792366 Replicon chromosome
Accession NZ_CP047527
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10648

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag DXN11_RS23510 Protein ID WP_000533909.1
Coordinates 4791606..4792091 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag DXN11_RS23515 Protein ID WP_000965886.1
Coordinates 4792079..4792366 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN11_RS23480 (4786676) 4786676..4787338 + 663 WP_000747548.1 OmpA family lipoprotein -
DXN11_RS23485 (4787557) 4787557..4788531 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
DXN11_RS23490 (4788581) 4788581..4789291 - 711 WP_000190524.1 DUF3053 domain-containing protein -
DXN11_RS23495 (4789730) 4789730..4790020 + 291 WP_000455790.1 HTH-type transcriptional regulator -
DXN11_RS23500 (4790309) 4790309..4790521 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
DXN11_RS23505 (4790695) 4790695..4791234 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
DXN11_RS23510 (4791606) 4791606..4792091 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
DXN11_RS23515 (4792079) 4792079..4792366 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
DXN11_RS23520 (4792544) 4792544..4793011 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
DXN11_RS23525 (4793183) 4793183..4793458 - 276 Protein_4587 IS3 family transposase -
DXN11_RS23530 (4793640) 4793640..4795709 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
DXN11_RS23535 (4795719) 4795719..4796630 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
DXN11_RS23540 (4796769) 4796769..4797071 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T146405 WP_000533909.1 NZ_CP047527:c4792091-4791606 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T146405 NZ_CP062746:c3062858-3062703 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT146405 WP_000965886.1 NZ_CP047527:c4792366-4792079 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT146405 NZ_CP062746:3062870-3062928 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2JDX2

References