Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4128130..4128790 Replicon chromosome
Accession NZ_CP047527
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10648

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag DXN11_RS20255 Protein ID WP_000244756.1
Coordinates 4128130..4128543 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag DXN11_RS20260 Protein ID WP_000351186.1
Coordinates 4128524..4128790 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN11_RS20235 (4124071) 4124071..4125804 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
DXN11_RS20240 (4125810) 4125810..4126523 - 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DXN11_RS20245 (4126547) 4126547..4127443 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
DXN11_RS20250 (4127556) 4127556..4128077 + 522 WP_001055885.1 flavodoxin FldB -
DXN11_RS20255 (4128130) 4128130..4128543 - 414 WP_000244756.1 protein YgfX Toxin
DXN11_RS20260 (4128524) 4128524..4128790 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
DXN11_RS20265 (4129040) 4129040..4130020 + 981 WP_000874172.1 tRNA-modifying protein YgfZ -
DXN11_RS20270 (4130136) 4130136..4130795 - 660 WP_000250289.1 hemolysin III family protein -
DXN11_RS20275 (4130959) 4130959..4131270 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
DXN11_RS20280 (4131429) 4131429..4132862 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T146402 WP_000244756.1 NZ_CP047527:c4128543-4128130 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T146402 NZ_CP062746:c2598393-2598286 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT146402 WP_000351186.1 NZ_CP047527:c4128790-4128524 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT146402 NZ_CP062746:2598441-2598500 [Escherichia coli O157:H7]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References