Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2513335..2513857 Replicon chromosome
Accession NZ_CP047527
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10648

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag DXN11_RS12270 Protein ID WP_000221343.1
Coordinates 2513335..2513619 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag DXN11_RS12275 Protein ID WP_000885424.1
Coordinates 2513609..2513857 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN11_RS12250 (2509410) 2509410..2510918 - 1509 WP_000199411.1 FAD-dependent oxidoreductase -
DXN11_RS12255 (2510963) 2510963..2511451 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
DXN11_RS12260 (2511644) 2511644..2512723 + 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
DXN11_RS12265 (2512775) 2512775..2513164 - 390 WP_000194089.1 RidA family protein -
DXN11_RS12270 (2513335) 2513335..2513619 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DXN11_RS12275 (2513609) 2513609..2513857 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DXN11_RS12280 (2514009) 2514009..2514224 + 216 WP_000206207.1 hypothetical protein -
DXN11_RS12285 (2514214) 2514214..2514546 + 333 WP_000253154.1 DUF1493 family protein -
DXN11_RS12290 (2514689) 2514689..2515597 + 909 WP_010989018.1 hypothetical protein -
DXN11_RS12295 (2515653) 2515653..2516367 - 715 Protein_2385 helix-turn-helix domain-containing protein -
DXN11_RS12300 (2517175) 2517175..2518641 - 1467 WP_000987828.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T146391 WP_000221343.1 NZ_CP047527:c2513619-2513335 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T146391 NZ_CP062746:283379-283486 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT146391 WP_000885424.1 NZ_CP047527:c2513857-2513609 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT146391 NZ_CP062746:c283331-283265 [Escherichia coli O157:H7]
GGTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References