Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1465155..1465775 Replicon chromosome
Accession NZ_CP047527
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10648

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag DXN11_RS07005 Protein ID WP_001280991.1
Coordinates 1465155..1465373 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag DXN11_RS07010 Protein ID WP_000344807.1
Coordinates 1465401..1465775 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN11_RS06965 (1460379) 1460379..1460948 + 570 WP_000779803.1 YbaY family lipoprotein -
DXN11_RS06970 (1460981) 1460981..1461370 - 390 WP_000961285.1 MGMT family protein -
DXN11_RS06980 (1461601) 1461601..1463151 - 1551 WP_000213139.1 EAL domain-containing protein -
DXN11_RS06985 (1463376) 1463376..1463636 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
DXN11_RS06990 (1463642) 1463642..1463782 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
DXN11_RS06995 (1463838) 1463838..1464308 - 471 WP_000136181.1 YlaC family protein -
DXN11_RS07000 (1464425) 1464425..1464976 - 552 WP_001278792.1 maltose O-acetyltransferase -
DXN11_RS07005 (1465155) 1465155..1465373 - 219 WP_001280991.1 HHA domain-containing protein Toxin
DXN11_RS07010 (1465401) 1465401..1465775 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
DXN11_RS07015 (1466271) 1466271..1469420 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
DXN11_RS07020 (1469443) 1469443..1470636 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T146390 WP_001280991.1 NZ_CP047527:c1465373-1465155 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T146390 NZ_CP062745:74039-74197 [Escherichia coli O157:H7]
ATGAAACTACCACGCAGCTCTCTTGTCTGGTGTGTGTTGATAGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGATACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT146390 WP_000344807.1 NZ_CP047527:c1465775-1465401 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT146390 NZ_CP062745:73776-73974 [Escherichia coli O157:H7]
TCACACGGATTGCCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAATGTGGTCAGCGTGCTGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References