Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 202700..204323 Replicon plasmid unnamed
Accession NZ_CP047526
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF11077

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag DXN14_RS25610 Protein ID WP_000088046.1
Coordinates 202700..204025 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag DXN14_RS25615 Protein ID WP_024136327.1
Coordinates 204030..204323 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN14_RS25580 (DXN14_025485) 199370..199669 - 300 WP_001572440.1 hypothetical protein -
DXN14_RS25585 (DXN14_025490) 199724..199960 - 237 Protein_209 type I restriction-modification system subunit M N-terminal domain-containing protein -
DXN14_RS25590 (DXN14_025495) 200414..200839 - 426 WP_001043843.1 hypothetical protein -
DXN14_RS25595 (DXN14_025500) 201093..201908 - 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
DXN14_RS25600 (DXN14_025505) 201921..202331 - 411 WP_000985911.1 hypothetical protein -
DXN14_RS25605 (DXN14_025510) 202433..202639 - 207 WP_000134171.1 hypothetical protein -
DXN14_RS25610 (DXN14_025515) 202700..204025 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
DXN14_RS25615 (DXN14_025520) 204030..204323 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
DXN14_RS25620 (DXN14_025525) 204927..205319 - 393 WP_000341066.1 hypothetical protein -
DXN14_RS25625 (DXN14_025530) 205692..206033 + 342 WP_001151575.1 hypothetical protein -
DXN14_RS25630 (DXN14_025535) 206125..206316 + 192 WP_000398480.1 hypothetical protein -
DXN14_RS25635 (DXN14_025540) 206366..206647 + 282 WP_000077926.1 hypothetical protein -
DXN14_RS25935 206988..207119 - 132 WP_000374059.1 hypothetical protein -
DXN14_RS25640 (DXN14_025545) 207210..208451 - 1242 WP_001053338.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid oqxB / oqxA / sul1 / dfrA12 / aph(3')-Ia / sul3 / ant(3'')-Ia / cmlA1 / aadA2 / floR / sul2 / aph(4)-Ia / aac(3)-IVa / aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / qacE - 1..249143 249143


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T146381 WP_000088046.1 NZ_CP047526:c204025-202700 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T146381 NZ_CP062744:4214004-4214222 [Escherichia coli O157:H7]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT146381 WP_024136327.1 NZ_CP047526:c204323-204030 [Salmonella enterica subsp. enterica serovar Typhimurium]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT146381 NZ_CP062744:4213604-4213978 [Escherichia coli O157:H7]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACTCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References