Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4485980..4486761 Replicon chromosome
Accession NZ_CP047525
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF11077

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag DXN14_RS22140 Protein ID WP_000626099.1
Coordinates 4485980..4486471 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag DXN14_RS22145 Protein ID WP_001110452.1
Coordinates 4486468..4486761 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN14_RS22100 (4481166) 4481166..4481408 - 243 WP_197603740.1 hypothetical protein -
DXN14_RS22105 (4481405) 4481405..4481761 - 357 WP_033567083.1 hypothetical protein -
DXN14_RS22110 (4481758) 4481758..4482630 - 873 WP_033567082.1 ParA family protein -
DXN14_RS22115 (4482821) 4482821..4482898 - 78 Protein_4334 helix-turn-helix domain-containing protein -
DXN14_RS22120 (4482989) 4482989..4483321 - 333 WP_001165471.1 MerR family transcriptional regulator -
DXN14_RS22125 (4483393) 4483393..4483770 + 378 WP_000916345.1 EthD family reductase -
DXN14_RS22130 (4484803) 4484803..4484877 + 75 Protein_4337 porin family protein -
DXN14_RS22135 (4484980) 4484980..4485732 + 753 WP_000842434.1 non-specific acid phosphatase -
DXN14_RS22140 (4485980) 4485980..4486471 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
DXN14_RS22145 (4486468) 4486468..4486761 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
DXN14_RS22150 (4487078) 4487078..4487299 + 222 WP_001576552.1 hypothetical protein -
DXN14_RS22155 (4487564) 4487564..4488439 + 876 WP_000921674.1 AraC family transcriptional regulator -
DXN14_RS22160 (4488436) 4488436..4488723 + 288 WP_001269916.1 transcriptional regulator RtsB -
DXN14_RS22165 (4488746) 4488746..4488961 + 216 WP_001595136.1 hypothetical protein -
DXN14_RS22170 (4488969) 4488969..4489238 + 270 WP_010989096.1 hypothetical protein -
DXN14_RS22175 (4489532) 4489532..4490437 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T146378 WP_000626099.1 NZ_CP047525:c4486471-4485980 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T146378 NZ_CP062744:c3575306-3575151 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT146378 WP_001110452.1 NZ_CP047525:c4486761-4486468 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT146378 NZ_CP062744:3575318-3575376 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References