146376

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4181667..4182243 Replicon chromosome
Accession NZ_CP047525
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF11077

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag DXN14_RS20640 Protein ID WP_001131963.1
Coordinates 4181956..4182243 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag DXN14_RS20635 Protein ID WP_000063142.1
Coordinates 4181667..4181969 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN14_RS20620 (4178177) 4178177..4180327 + 2151 WP_000379927.1 pyruvate/proton symporter BtsT -
DXN14_RS20625 (4180422) 4180422..4180625 + 204 WP_000460616.1 YbdD/YjiX family protein -
DXN14_RS20630 (4180636) 4180636..4181592 + 957 WP_000187839.1 GTPase -
DXN14_RS20635 (4181667) 4181667..4181969 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
DXN14_RS20640 (4181956) 4181956..4182243 - 288 WP_001131963.1 BrnT family toxin Toxin
DXN14_RS20645 (4182512) 4182512..4183426 - 915 WP_000290512.1 restriction endonuclease -
DXN14_RS20650 (4183624) 4183624..4187133 + 3510 WP_001043484.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T146376 WP_001131963.1 NZ_CP047525:c4182243-4181956 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T146376 NZ_CP062744:c3066735-3066580 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT146376 WP_000063142.1 NZ_CP047525:c4181969-4181667 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT146376 NZ_CP062744:3066747-3066805 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6PB01

References