Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3536494..3537114 Replicon chromosome
Accession NZ_CP047525
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF11077

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag DXN14_RS17515 Protein ID WP_001280991.1
Coordinates 3536896..3537114 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag DXN14_RS17510 Protein ID WP_000344807.1
Coordinates 3536494..3536868 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN14_RS17500 (3531633) 3531633..3532826 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DXN14_RS17505 (3532849) 3532849..3535998 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
DXN14_RS17510 (3536494) 3536494..3536868 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
DXN14_RS17515 (3536896) 3536896..3537114 + 219 WP_001280991.1 HHA domain-containing protein Toxin
DXN14_RS17520 (3537293) 3537293..3537844 + 552 WP_001278792.1 maltose O-acetyltransferase -
DXN14_RS17525 (3537961) 3537961..3538431 + 471 WP_000136181.1 YlaC family protein -
DXN14_RS17530 (3538487) 3538487..3538627 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
DXN14_RS17535 (3538633) 3538633..3538893 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
DXN14_RS17540 (3539118) 3539118..3540668 + 1551 WP_000213139.1 EAL domain-containing protein -
DXN14_RS17550 (3540899) 3540899..3541288 + 390 WP_000961285.1 MGMT family protein -
DXN14_RS17555 (3541321) 3541321..3541890 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T146372 WP_001280991.1 NZ_CP047525:3536896-3537114 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T146372 NZ_CP062744:c2601729-2601622 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT146372 WP_000344807.1 NZ_CP047525:3536494-3536868 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT146372 NZ_CP062744:2601782-2601843 [Escherichia coli O157:H7]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References