Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 206694..207454 Replicon chromosome
Accession NZ_CP047525
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF11077

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag DXN14_RS00965 Protein ID WP_000533909.1
Coordinates 206969..207454 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag DXN14_RS00960 Protein ID WP_000965886.1
Coordinates 206694..206981 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN14_RS00935 (201989) 201989..202291 + 303 WP_000605590.1 YsaB family lipoprotein -
DXN14_RS00940 (202430) 202430..203341 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
DXN14_RS00945 (203351) 203351..205420 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
DXN14_RS00950 (205602) 205602..205877 + 276 Protein_189 IS3 family transposase -
DXN14_RS00955 (206049) 206049..206516 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
DXN14_RS00960 (206694) 206694..206981 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
DXN14_RS00965 (206969) 206969..207454 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
DXN14_RS00970 (207826) 207826..208365 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
DXN14_RS00975 (208539) 208539..208751 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
DXN14_RS00980 (209040) 209040..209330 - 291 WP_000455790.1 HTH-type transcriptional regulator -
DXN14_RS00985 (209769) 209769..210479 + 711 WP_000190524.1 DUF3053 domain-containing protein -
DXN14_RS00990 (210529) 210529..211503 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
DXN14_RS00995 (211722) 211722..212384 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T146357 WP_000533909.1 NZ_CP047525:206969-207454 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T146357 NZ_CP062742:c4959668-4959318 [Escherichia coli O157:H7]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT146357 WP_000965886.1 NZ_CP047525:206694-206981 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT146357 NZ_CP062742:c4959913-4959662 [Escherichia coli O157:H7]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGTGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References