Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 17182..17729 Replicon plasmid unnamedB
Accession NZ_CP047524
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF11216

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag DXN15_RS25210 Protein ID WP_001384452.1
Coordinates 17451..17729 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0S0ZPX5
Locus tag DXN15_RS25205 Protein ID WP_032291093.1
Coordinates 17182..17451 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN15_RS25180 (12825) 12825..13358 - 534 WP_001372168.1 transcription termination/antitermination NusG family protein -
DXN15_RS25185 (13800) 13800..14087 - 288 WP_000074855.1 conjugal transfer protein TraA -
DXN15_RS25190 (14125) 14125..14283 - 159 Protein_15 ash family protein -
DXN15_RS25195 (15240) 15240..16271 + 1032 WP_023518831.1 plasmid replication initiator RepA -
DXN15_RS25200 (16969) 16969..17127 + 159 WP_038349023.1 hypothetical protein -
DXN15_RS25205 (17182) 17182..17451 + 270 WP_032291093.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
DXN15_RS25210 (17451) 17451..17729 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
DXN15_RS25215 (17769) 17769..18617 + 849 WP_032291092.1 3'-5' exonuclease -
DXN15_RS25220 (18933) 18933..19442 - 510 WP_032291091.1 hypothetical protein -
DXN15_RS25225 (19498) 19498..20100 - 603 WP_000517687.1 ProQ/FINO family protein -
DXN15_RS25230 (20453) 20453..21799 + 1347 WP_001132021.1 protein YagA -
DXN15_RS25235 (22326) 22326..22628 - 303 WP_001245884.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-14 - 1..87292 87292


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T146352 WP_001384452.1 NZ_CP047524:17451-17729 [Salmonella enterica subsp. enterica serovar Typhimurium]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

>T146352 NZ_CP062742:4214067-4214285 [Escherichia coli O157:H7]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10069.43 Da        Isoelectric Point: 8.0565

>AT146352 WP_032291093.1 NZ_CP047524:17182-17451 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLGCGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT146352 NZ_CP062742:4213667-4214041 [Escherichia coli O157:H7]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACTCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A0S0ZPX5

References