Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 93949..95572 Replicon plasmid unnamedA
Accession NZ_CP047523
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF11216

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag DXN15_RS24640 Protein ID WP_000088046.1
Coordinates 93949..95274 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag DXN15_RS24645 Protein ID WP_024136327.1
Coordinates 95279..95572 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN15_RS24610 (DXN15_024560) 90619..90918 - 300 WP_001572440.1 hypothetical protein -
DXN15_RS24615 (DXN15_024565) 90973..91209 - 237 Protein_105 type I restriction-modification system subunit M N-terminal domain-containing protein -
DXN15_RS24620 (DXN15_024570) 91663..92088 - 426 WP_001043843.1 hypothetical protein -
DXN15_RS24625 (DXN15_024575) 92342..93157 - 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
DXN15_RS24630 (DXN15_024580) 93170..93580 - 411 WP_000985911.1 hypothetical protein -
DXN15_RS24635 (DXN15_024585) 93682..93888 - 207 WP_000134171.1 hypothetical protein -
DXN15_RS24640 (DXN15_024590) 93949..95274 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
DXN15_RS24645 (DXN15_024595) 95279..95572 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
DXN15_RS24650 (DXN15_024600) 96176..96568 - 393 WP_000341066.1 hypothetical protein -
DXN15_RS24655 (DXN15_024605) 96941..97282 + 342 WP_001151575.1 hypothetical protein -
DXN15_RS24660 (DXN15_024610) 97374..97565 + 192 WP_000398480.1 hypothetical protein -
DXN15_RS24665 (DXN15_024615) 97615..97896 + 282 WP_000077926.1 hypothetical protein -
DXN15_RS25665 98237..98368 - 132 WP_000374059.1 hypothetical protein -
DXN15_RS24670 (DXN15_024620) 98459..99700 - 1242 WP_001053338.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / dfrA12 / aph(3')-Ia / sul3 / ant(3'')-Ia / cmlA1 / aadA2 / floR / sul2 / aph(4)-Ia / aac(3)-IVa / aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / qacE - 1..195873 195873


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T146351 WP_000088046.1 NZ_CP047523:c95274-93949 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T146351 NZ_CP062742:3757627-3758013 [Escherichia coli O157:H7]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT146351 WP_024136327.1 NZ_CP047523:c95572-95279 [Salmonella enterica subsp. enterica serovar Typhimurium]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT146351 NZ_CP062742:3758003-3758332 [Escherichia coli O157:H7]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References