Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4733878..4734638 Replicon chromosome
Accession NZ_CP047522
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF11216

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag DXN15_RS23125 Protein ID WP_000533909.1
Coordinates 4733878..4734363 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag DXN15_RS23130 Protein ID WP_000965886.1
Coordinates 4734351..4734638 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN15_RS23095 (4728948) 4728948..4729610 + 663 WP_000747548.1 OmpA family lipoprotein -
DXN15_RS23100 (4729829) 4729829..4730803 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
DXN15_RS23105 (4730853) 4730853..4731563 - 711 WP_000190524.1 DUF3053 domain-containing protein -
DXN15_RS23110 (4732002) 4732002..4732292 + 291 WP_000455790.1 HTH-type transcriptional regulator -
DXN15_RS23115 (4732581) 4732581..4732793 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
DXN15_RS23120 (4732967) 4732967..4733506 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
DXN15_RS23125 (4733878) 4733878..4734363 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
DXN15_RS23130 (4734351) 4734351..4734638 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
DXN15_RS23135 (4734816) 4734816..4735283 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
DXN15_RS23140 (4735455) 4735455..4735730 - 276 Protein_4510 IS3 family transposase -
DXN15_RS23145 (4735912) 4735912..4737981 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
DXN15_RS23150 (4737991) 4737991..4738902 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
DXN15_RS23155 (4739041) 4739041..4739343 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T146350 WP_000533909.1 NZ_CP047522:c4734363-4733878 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T146350 NZ_CP062742:3591664-3591951 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT146350 WP_000965886.1 NZ_CP047522:c4734638-4734351 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT146350 NZ_CP062742:3591473-3591664 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References