Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4070219..4070879 Replicon chromosome
Accession NZ_CP047522
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF11216

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag DXN15_RS19865 Protein ID WP_000244756.1
Coordinates 4070219..4070632 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag DXN15_RS19870 Protein ID WP_000351186.1
Coordinates 4070613..4070879 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN15_RS19845 (4066160) 4066160..4067893 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
DXN15_RS19850 (4067899) 4067899..4068612 - 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DXN15_RS19855 (4068636) 4068636..4069532 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
DXN15_RS19860 (4069645) 4069645..4070166 + 522 WP_001055885.1 flavodoxin FldB -
DXN15_RS19865 (4070219) 4070219..4070632 - 414 WP_000244756.1 protein YgfX Toxin
DXN15_RS19870 (4070613) 4070613..4070879 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
DXN15_RS19875 (4071129) 4071129..4072109 + 981 WP_000874172.1 tRNA-modifying protein YgfZ -
DXN15_RS19880 (4072225) 4072225..4072884 - 660 WP_000250289.1 hemolysin III family protein -
DXN15_RS19885 (4073048) 4073048..4073359 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
DXN15_RS19890 (4073518) 4073518..4074951 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T146347 WP_000244756.1 NZ_CP047522:c4070632-4070219 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T146347 NZ_CP062742:3112300-3112407 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT146347 WP_000351186.1 NZ_CP047522:c4070879-4070613 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT146347 NZ_CP062742:c3112247-3112186 [Escherichia coli O157:H7]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References