Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 516563..517344 | Replicon | chromosome |
| Accession | NZ_CP047522 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF11216 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | DXN15_RS02400 | Protein ID | WP_000626099.1 |
| Coordinates | 516853..517344 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | DXN15_RS02395 | Protein ID | WP_001110452.1 |
| Coordinates | 516563..516856 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DXN15_RS02365 (512887) | 512887..513792 | + | 906 | WP_001268200.1 | YjiK family protein | - |
| DXN15_RS02370 (514086) | 514086..514355 | - | 270 | WP_010989096.1 | hypothetical protein | - |
| DXN15_RS02375 (514363) | 514363..514578 | - | 216 | WP_001595136.1 | hypothetical protein | - |
| DXN15_RS02380 (514601) | 514601..514888 | - | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| DXN15_RS02385 (514885) | 514885..515760 | - | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| DXN15_RS02390 (516025) | 516025..516246 | - | 222 | WP_001576552.1 | hypothetical protein | - |
| DXN15_RS02395 (516563) | 516563..516856 | + | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| DXN15_RS02400 (516853) | 516853..517344 | + | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| DXN15_RS02405 (517592) | 517592..518344 | - | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| DXN15_RS02410 (518447) | 518447..518521 | - | 75 | Protein_452 | porin family protein | - |
| DXN15_RS02415 (519554) | 519554..519931 | - | 378 | WP_000916345.1 | EthD family reductase | - |
| DXN15_RS02420 (520003) | 520003..520335 | + | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| DXN15_RS02425 (520426) | 520426..520503 | + | 78 | Protein_455 | helix-turn-helix domain-containing protein | - |
| DXN15_RS02430 (520694) | 520694..521566 | + | 873 | WP_033567082.1 | ParA family protein | - |
| DXN15_RS02435 (521563) | 521563..521919 | + | 357 | WP_033567083.1 | hypothetical protein | - |
| DXN15_RS02440 (521916) | 521916..522158 | + | 243 | WP_197603740.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T146329 WP_000626099.1 NZ_CP047522:516853-517344 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T146329 NZ_CP062740:2066-2341 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT146329 WP_001110452.1 NZ_CP047522:516563-516856 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT146329 NZ_CP062740:1782-2066 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 | |
| AlphaFold DB | A0A5I1DGA4 |