Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4666584..4667137 Replicon chromosome
Accession NZ_CP047495
Organism Pectobacterium brasiliense strain 1692

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag GT391_RS20895 Protein ID WP_010287537.1
Coordinates 4666584..4666898 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag GT391_RS20900 Protein ID WP_010287535.1
Coordinates 4666901..4667137 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GT391_RS20870 4661763..4663625 + 1863 WP_159398234.1 type IV secretory system conjugative DNA transfer family protein -
GT391_RS20875 4663634..4664380 + 747 WP_039320867.1 hypothetical protein -
GT391_RS20880 4664786..4665253 + 468 WP_199559768.1 Lrp/AsnC family transcriptional regulator -
GT391_RS20885 4665250..4666110 - 861 WP_010287540.1 EamA family transporter -
GT391_RS20890 4666296..4666550 + 255 WP_039320862.1 hypothetical protein -
GT391_RS20895 4666584..4666898 - 315 WP_010287537.1 CcdB family protein Toxin
GT391_RS20900 4666901..4667137 - 237 WP_010287535.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
GT391_RS20905 4667457..4668401 - 945 WP_159398235.1 DUF1738 domain-containing protein -
GT391_RS20910 4668787..4669509 + 723 WP_072014229.1 MurR/RpiR family transcriptional regulator -
GT391_RS20915 4669687..4671114 + 1428 WP_010284508.1 glycoside hydrolase family 1 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4641211..4681021 39810


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11493.40 Da        Isoelectric Point: 7.9859

>T146325 WP_010287537.1 NZ_CP047495:c4666898-4666584 [Pectobacterium brasiliense]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIAIPLLPIEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRSQVKAAIDFLIDGF

Download         Length: 315 bp

>T146325 NZ_CP062739:c4920007-4919693 [Escherichia coli O157:H7]
ATGCAATTTACGGTATACCGCAGTCGCAGTAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8964.00 Da        Isoelectric Point: 6.7173

>AT146325 WP_010287535.1 NZ_CP047495:c4667137-4666901 [Pectobacterium brasiliense]
MTAKQRNTQSVTMTVERALLVRARAAGINLSATLTTALDAELRHHEAKKWQEENREAIDALNRFHDEQGCFSDEYRTF

Download         Length: 237 bp

>AT146325 NZ_CP062739:c4920243-4920010 [Escherichia coli O157:H7]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References