Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 2994106..2994769 Replicon chromosome
Accession NZ_CP047495
Organism Pectobacterium brasiliense strain 1692

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag GT391_RS13375 Protein ID WP_010279985.1
Coordinates 2994425..2994769 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag GT391_RS13370 Protein ID WP_010279989.1
Coordinates 2994106..2994423 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GT391_RS13340 2990163..2991041 - 879 WP_010280003.1 aldo/keto reductase family oxidoreductase -
GT391_RS13345 2991071..2991994 - 924 WP_010280001.1 NADP-dependent oxidoreductase -
GT391_RS13350 2992112..2992714 + 603 WP_039316571.1 TetR/AcrR family transcriptional regulator -
GT391_RS13355 2992804..2993142 - 339 WP_010279998.1 putative addiction module antidote protein -
GT391_RS13360 2993147..2993455 - 309 WP_052051616.1 addiction module killer protein -
GT391_RS13365 2993802..2994017 + 216 WP_010279992.1 helix-turn-helix domain-containing protein -
GT391_RS13370 2994106..2994423 - 318 WP_010279989.1 helix-turn-helix domain-containing protein Antitoxin
GT391_RS13375 2994425..2994769 - 345 WP_010279985.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GT391_RS13380 2995059..2996528 - 1470 WP_010279982.1 SEL1-like repeat protein -
GT391_RS13385 2996634..2996872 - 239 Protein_2590 helix-turn-helix domain-containing protein -
GT391_RS13390 2996965..2997271 + 307 Protein_2591 hypothetical protein -
GT391_RS13395 2997413..2999098 - 1686 WP_010279977.1 discoidin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-86)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12373.09 Da        Isoelectric Point: 9.7825

>T146322 WP_010279985.1 NZ_CP047495:c2994769-2994425 [Pectobacterium brasiliense]
MKSLYWVGSSKKDLQSLPADVQDVFGYALHVAQTGGKHTQAKPLKGFGGAGVLEVVEDYIGDTYRAVYTVKFGEAVYVLH
AFQKKSSSGIATPKPDMNTIRERLKTAENHAKGA

Download         Length: 345 bp

>T146322 NZ_CP062739:4424793-4425011 [Escherichia coli O157:H7]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11475.50 Da        Isoelectric Point: 10.6133

>AT146322 WP_010279989.1 NZ_CP047495:c2994423-2994106 [Pectobacterium brasiliense]
MSQDIEVSSGNVYADLGNLHAEDMLVKAQLATLISSIIKNRRLTQAEAAKLLGMPQPKLSNLLRGQFRGISETKMLECLT
KLGRDIQIVVGKPRRTPGSVKVVFA

Download         Length: 318 bp

>AT146322 NZ_CP062739:4424393-4424767 [Escherichia coli O157:H7]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACTCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References