Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2360587..2361137 Replicon chromosome
Accession NZ_CP047495
Organism Pectobacterium brasiliense strain 1692

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag GT391_RS10580 Protein ID WP_010681729.1
Coordinates 2360587..2360895 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag GT391_RS10585 Protein ID WP_010681728.1
Coordinates 2360898..2361137 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GT391_RS10560 2356340..2357245 - 906 WP_010681733.1 LysR family transcriptional regulator -
GT391_RS10565 2357530..2358459 + 930 WP_010681732.1 aromatic alcohol reductase -
GT391_RS10570 2358510..2360168 - 1659 WP_010681731.1 HTH-type transcriptional regulator SgrR -
GT391_RS10575 2360259..2360423 + 165 WP_010681730.1 glucose uptake inhibitor SgrT -
GT391_RS10580 2360587..2360895 - 309 WP_010681729.1 CcdB family protein Toxin
GT391_RS10585 2360898..2361137 - 240 WP_010681728.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
GT391_RS10590 2361838..2363457 + 1620 WP_010681727.1 Tar ligand binding domain-containing protein -
GT391_RS10595 2363671..2364507 + 837 WP_010681726.1 AraC family transcriptional regulator -
GT391_RS10600 2364613..2365347 + 735 WP_039319075.1 AzlC family ABC transporter permease -
GT391_RS10605 2365344..2365655 + 312 WP_010681724.1 AzlD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11802.59 Da        Isoelectric Point: 8.4503

>T146321 WP_010681729.1 NZ_CP047495:c2360895-2360587 [Pectobacterium brasiliense]
MQYKVYRNNGNNNSYPYLLNVQSDIIGELHTRLVIPLFPVHNIARPPARRLTPIVTVEGNDYLIMTHEMASVRRSQLGHE
VMDAQMYRKTIKDAVDFLLDGF

Download         Length: 309 bp

>T146321 NZ_CP062739:3968353-3968739 [Escherichia coli O157:H7]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9054.40 Da        Isoelectric Point: 10.0137

>AT146321 WP_010681728.1 NZ_CP047495:c2361137-2360898 [Pectobacterium brasiliense]
MPVTSVRHKKTVSVTLEPMLLQQAREAGINLSAILTEALKREIRLSEGEKWKQQNQKALQELNRITDKHGLLSDDDRTF

Download         Length: 240 bp

>AT146321 NZ_CP062739:3968729-3969058 [Escherichia coli O157:H7]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References