Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 1829047..1829664 | Replicon | chromosome |
Accession | NZ_CP047495 | ||
Organism | Pectobacterium brasiliense strain 1692 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | C6DHN3 |
Locus tag | GT391_RS08155 | Protein ID | WP_010281507.1 |
Coordinates | 1829485..1829664 (-) | Length | 60 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A0M2EY98 |
Locus tag | GT391_RS08150 | Protein ID | WP_010281508.1 |
Coordinates | 1829047..1829457 (-) | Length | 137 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GT391_RS08135 | 1824912..1825955 | - | 1044 | WP_010281514.1 | DNA-binding transcriptional regulator CytR | - |
GT391_RS08140 | 1826264..1828462 | - | 2199 | WP_010281513.1 | primosomal protein N' | - |
GT391_RS08145 | 1828735..1828950 | + | 216 | WP_010281510.1 | 50S ribosomal protein L31 | - |
GT391_RS08150 | 1829047..1829457 | - | 411 | WP_010281508.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
GT391_RS08155 | 1829485..1829664 | - | 180 | WP_010281507.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
GT391_RS08160 | 1829748..1830758 | - | 1011 | WP_010281503.1 | iron ABC transporter permease | - |
GT391_RS08165 | 1830755..1831717 | - | 963 | WP_010281502.1 | ABC transporter substrate-binding protein | - |
GT391_RS08170 | 1831727..1832524 | - | 798 | WP_010281500.1 | ABC transporter ATP-binding protein | - |
GT391_RS08175 | 1832758..1833075 | - | 318 | WP_005973355.1 | met regulon transcriptional regulator MetJ | - |
GT391_RS08180 | 1833263..1834423 | + | 1161 | WP_010281494.1 | cystathionine gamma-synthase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6560.69 Da Isoelectric Point: 10.7838
>T146320 WP_010281507.1 NZ_CP047495:c1829664-1829485 [Pectobacterium brasiliense]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI
Download Length: 180 bp
>T146320 NZ_CP062739:3793039-3793326 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA
Antitoxin
Download Length: 137 a.a. Molecular weight: 14492.40 Da Isoelectric Point: 4.4493
>AT146320 WP_010281508.1 NZ_CP047495:c1829457-1829047 [Pectobacterium brasiliense]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLIEMGQDVPTVSSVGKLAKSAEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLIEMGQDVPTVSSVGKLAKSAEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR
Download Length: 411 bp
>AT146320 NZ_CP062739:3792848-3793039 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7W2I1S0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0M2EY98 |