Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 1774074..1774825 Replicon chromosome
Accession NZ_CP047495
Organism Pectobacterium brasiliense strain 1692

Toxin (Protein)


Gene name ataT Uniprot ID A0A433N1V3
Locus tag GT391_RS07905 Protein ID WP_010281603.1
Coordinates 1774343..1774825 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A0M2EWB4
Locus tag GT391_RS07900 Protein ID WP_039317395.1
Coordinates 1774074..1774352 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GT391_RS07860 1769615..1770529 - 915 WP_039320187.1 NAD(P)-dependent oxidoreductase -
GT391_RS07865 1770868..1771626 + 759 WP_010281613.1 DeoR/GlpR family DNA-binding transcription regulator -
GT391_RS07870 1771648..1771977 - 330 WP_039320190.1 helix-turn-helix domain-containing protein -
GT391_RS07875 1771928..1772353 - 426 WP_010281610.1 type II toxin-antitoxin system RelE/ParE family toxin -
GT391_RS07885 1772852..1773151 + 300 WP_010281608.1 hypothetical protein -
GT391_RS07890 1773148..1773546 + 399 WP_072014222.1 hypothetical protein -
GT391_RS07895 1773548..1773964 + 417 WP_039320235.1 hypothetical protein -
GT391_RS07900 1774074..1774352 + 279 WP_039317395.1 DUF1778 domain-containing protein Antitoxin
GT391_RS07905 1774343..1774825 + 483 WP_010281603.1 GNAT family N-acetyltransferase Toxin
GT391_RS07910 1774958..1776292 + 1335 WP_010281601.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
GT391_RS07915 1776365..1777252 + 888 WP_010281599.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
GT391_RS07920 1777278..1778123 + 846 WP_010281598.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
GT391_RS07925 1778398..1779471 + 1074 WP_010281596.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(39-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-92)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17509.30 Da        Isoelectric Point: 9.0439

>T146319 WP_010281603.1 NZ_CP047495:1774343-1774825 [Pectobacterium brasiliense]
MGITAPEPLSSSHNLAEFCSQEPSLNEWLKKKALKNHSAGISRVYVICAEGTHQVIGYYCLSTGSVQRNTAPGAYRRNAP
ESLPVIVLGRLAIDQAYSGKGLGVALLKDAIFRTENIALQVGVRALVVHALDENVRNFYLKFAFDPSPVQPLMLLYPIKI

Download         Length: 483 bp

>T146319 NZ_CP062739:c3786093-3785938 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10667.12 Da        Isoelectric Point: 4.3611

>AT146319 WP_039317395.1 NZ_CP047495:1774074-1774352 [Pectobacterium brasiliense]
MKPETKEAPINIRAKASQRDLIDMAANLVSKSRTDFMLEAACREAQDILLDQRLFILDNEQFDEFLAELDAPITEERQAR
INDLMSRKSPWE

Download         Length: 279 bp

>AT146319 NZ_CP062739:3786105-3786163 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A433N1V3

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2EWB4

References