Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1484998..1485533 Replicon chromosome
Accession NZ_CP047495
Organism Pectobacterium brasiliense strain 1692

Toxin (Protein)


Gene name relE Uniprot ID A0A0M2F065
Locus tag GT391_RS06615 Protein ID WP_010281709.1
Coordinates 1485246..1485533 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q6DB37
Locus tag GT391_RS06610 Protein ID WP_010281712.1
Coordinates 1484998..1485249 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GT391_RS06585 1480555..1481427 + 873 WP_010281722.1 LysR family transcriptional regulator -
GT391_RS06590 1481471..1482094 - 624 WP_010281721.1 LysE family translocator -
GT391_RS06595 1482276..1482980 + 705 WP_010281718.1 SMI1/KNR4 family protein -
GT391_RS06600 1483050..1483805 + 756 WP_010281715.1 thiol:disulfide interchange protein DsbG -
GT391_RS06605 1483839..1484744 - 906 WP_039320731.1 siderophore-interacting protein -
GT391_RS06610 1484998..1485249 + 252 WP_010281712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GT391_RS06615 1485246..1485533 + 288 WP_010281709.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GT391_RS06620 1485653..1487005 - 1353 WP_010281708.1 glutathione-disulfide reductase -
GT391_RS06625 1487134..1487976 - 843 WP_010281707.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
GT391_RS06630 1488195..1488923 + 729 WP_010281706.1 DUF1266 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10911.96 Da        Isoelectric Point: 10.4361

>T146317 WP_010281709.1 NZ_CP047495:1485246-1485533 [Pectobacterium brasiliense]
MSCSVKFREDALKEWLKLDKTIQQQFAKKLKKCCENPHIPSAKLRGVKDCYKIKLRASGFRLVYEVIDDILTIAVVAVGK
RGRSGVYHLASERMR

Download         Length: 288 bp

>T146317 NZ_CP062739:3275647-3275925 [Escherichia coli O157:H7]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9117.47 Da        Isoelectric Point: 4.0637

>AT146317 WP_010281712.1 NZ_CP047495:1484998-1485249 [Pectobacterium brasiliense]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVDVDLD
SFL

Download         Length: 252 bp

>AT146317 NZ_CP062739:3275454-3275645 [Escherichia coli O157:H7]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2F065

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2EZP0

References