Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 339805..340430 Replicon chromosome
Accession NZ_CP047495
Organism Pectobacterium brasiliense strain 1692

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag GT391_RS01485 Protein ID WP_005976087.1
Coordinates 340227..340430 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q6D809
Locus tag GT391_RS01480 Protein ID WP_010282247.1
Coordinates 339805..340173 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GT391_RS01465 335436..338564 + 3129 WP_039312320.1 multidrug efflux RND transporter permease subunit -
GT391_RS01470 338797..339045 + 249 WP_010282248.1 type B 50S ribosomal protein L31 -
GT391_RS01475 339063..339206 + 144 WP_005976091.1 type B 50S ribosomal protein L36 -
GT391_RS01480 339805..340173 + 369 WP_010282247.1 Hha toxicity modulator TomB Antitoxin
GT391_RS01485 340227..340430 + 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
GT391_RS01495 341172..341492 + 321 WP_010282239.1 MGMT family protein -
GT391_RS01500 341512..342093 - 582 WP_010282236.1 YbaY family lipoprotein -
GT391_RS01505 342306..343169 + 864 WP_010282232.1 acyl-CoA thioesterase II -
GT391_RS01510 343309..344595 - 1287 WP_010282229.1 ammonium transporter AmtB -
GT391_RS01515 344635..344973 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T146312 WP_005976087.1 NZ_CP047495:340227-340430 [Pectobacterium brasiliense]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T146312 NZ_CP062739:c2208917-2208810 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14046.80 Da        Isoelectric Point: 4.4787

>AT146312 WP_010282247.1 NZ_CP047495:339805-340173 [Pectobacterium brasiliense]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENICTPAKT

Download         Length: 369 bp

>AT146312 NZ_CP062739:2208965-2209024 [Escherichia coli O157:H7]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A086EI31

References