Detailed information of TA system TA146309

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2204775..2205331
• Replicon: chromosome
• Accession: NZ_CP047493
• Organism: Xanthomonas oryzae pv. oryzae strain IXO792

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: IXO792_RS10540
• Protein ID: WP_229001948.1
• Coordinates: 2205080..2205331 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: IXO792_RS10535
• Protein ID: WP_011408759.1
• Coordinates: 2204775..2205053 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IXO792_RS10520 (IXO792_10440)	2200959..2202194	+	1236	WP_044756360.1	ISL3-like element ISXoo13 family transposase	-
IXO792_RS10525 (IXO792_10445)	2202523..2203758	-	1236	WP_012443979.1	ISL3-like element ISXoo13 family transposase	-
IXO792_RS10530 (IXO792_10455)	2204235..2204579	+	345	WP_199285675.1	hypothetical protein	-
IXO792_RS10535 (IXO792_10460)	2204775..2205053	+	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
IXO792_RS10540 (IXO792_10465)	2205080..2205331	+	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IXO792_RS10545 (IXO792_10470)	2205408..2205662	+	255	WP_198912806.1	hypothetical protein	-
IXO792_RS10550	2205655..2205789	+	135	WP_011051575.1	hypothetical protein	-
IXO792_RS10555 (IXO792_10475)	2205858..2206112	+	255	WP_223293127.1	hypothetical protein	-
IXO792_RS10560	2206329..2206448	+	120	Protein_2014	IS3 family transposase	-
IXO792_RS10565	2206417..2206545	+	129	WP_012444694.1	hypothetical protein	-
IXO792_RS10575 (IXO792_10490)	2206976..2207377	-	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
IXO792_RS10580	2207599..2207775	+	177	Protein_2017	DUF3606 domain-containing protein	-
IXO792_RS10585 (IXO792_10500)	2208057..2208373	+	317	Protein_2018	ATP-dependent DNA ligase	-
IXO792_RS10590 (IXO792_10505)	2208470..2209561	-	1092	WP_075239568.1	ribonuclease D	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T146309 WP_229001948.1 NZ_CP047493:2205080-2205331 [Xanthomonas oryzae pv. oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T146309 NZ_CP062739:946473-946880 [Escherichia coli O157:H7]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT146309 WP_011408759.1 NZ_CP047493:2204775-2205053 [Xanthomonas oryzae pv. oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT146309 NZ_CP062739:946226-946492 [Escherichia coli O157:H7]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2