Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4802344..4803104 Replicon chromosome
Accession NZ_CP047424
Organism Salmonella enterica subsp. enterica serovar Dessau strain KUFSE-SAL0043

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag GTK42_RS23125 Protein ID WP_000533909.1
Coordinates 4802619..4803104 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag GTK42_RS23120 Protein ID WP_000965889.1
Coordinates 4802344..4802631 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTK42_RS23535 (4798770) 4798770..4799171 + 402 Protein_4520 IS3 family transposase -
GTK42_RS23110 (4799397) 4799397..4800167 - 771 WP_000456879.1 DUF3800 domain-containing protein -
GTK42_RS23540 (4801194) 4801194..4802138 + 945 WP_001804716.1 HNH endonuclease signature motif containing protein -
GTK42_RS23120 (4802344) 4802344..4802631 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
GTK42_RS23125 (4802619) 4802619..4803104 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
GTK42_RS23130 (4803476) 4803476..4804015 - 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
GTK42_RS23135 (4804188) 4804188..4804400 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
GTK42_RS23140 (4804688) 4804688..4804978 - 291 WP_000455790.1 HTH-type transcriptional regulator -
GTK42_RS23145 (4805417) 4805417..4806127 + 711 WP_000190524.1 DUF3053 domain-containing protein -
GTK42_RS23150 (4806177) 4806177..4807151 - 975 WP_000804670.1 glyoxylate/hydroxypyruvate reductase GhrB -
GTK42_RS23155 (4807381) 4807381..4808043 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T146226 WP_000533909.1 NZ_CP047424:4802619-4803104 [Salmonella enterica subsp. enterica serovar Dessau]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T146226 NZ_CP062731:3110431-3110538 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT146226 WP_000965889.1 NZ_CP047424:4802344-4802631 [Salmonella enterica subsp. enterica serovar Dessau]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT146226 NZ_CP062731:c3110383-3110324 [Escherichia coli O157:H7]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References