Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3908826..3909342 Replicon chromosome
Accession NZ_CP047424
Organism Salmonella enterica subsp. enterica serovar Dessau strain KUFSE-SAL0043

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag GTK42_RS18865 Protein ID WP_000220577.1
Coordinates 3908826..3909110 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag GTK42_RS18870 Protein ID WP_000212724.1
Coordinates 3909100..3909342 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTK42_RS18850 (3904038) 3904038..3905690 + 1653 WP_000155037.1 alpha,alpha-phosphotrehalase -
GTK42_RS18855 (3906099) 3906099..3908237 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
GTK42_RS18860 (3908358) 3908358..3908822 + 465 WP_001268863.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
GTK42_RS18865 (3908826) 3908826..3909110 - 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTK42_RS18870 (3909100) 3909100..3909342 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GTK42_RS18875 (3909420) 3909420..3911333 - 1914 WP_001212145.1 BglG family transcription antiterminator -
GTK42_RS18880 (3911350) 3911350..3912090 - 741 WP_000779267.1 KDGP aldolase family protein -
GTK42_RS18885 (3912087) 3912087..3913205 - 1119 WP_001139181.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
GTK42_RS18890 (3913189) 3913189..3914322 - 1134 WP_000459941.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T146223 WP_000220577.1 NZ_CP047424:c3909110-3908826 [Salmonella enterica subsp. enterica serovar Dessau]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T146223 NZ_CP062731:2645958-2646113 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT146223 WP_000212724.1 NZ_CP047424:c3909342-3909100 [Salmonella enterica subsp. enterica serovar Dessau]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT146223 NZ_CP062731:c2645946-2645888 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References