Detailed information of TA system TA146206

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 2158934..2159456
• Replicon: chromosome
• Accession: NZ_CP047424
• Organism: Salmonella enterica subsp. enterica serovar Dessau strain KUFSE-SAL0043

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: A0A8E5IJC7
• Locus tag: GTK42_RS10520
• Protein ID: WP_000221347.1
• Coordinates: 2158934..2159218 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: GTK42_RS10525
• Protein ID: WP_000885424.1
• Coordinates: 2159208..2159456 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GTK42_RS10500 (2155009)	2155009..2156517	-	1509	WP_000199412.1	FAD-dependent oxidoreductase	-
GTK42_RS10505 (2156562)	2156562..2157050	+	489	WP_001293634.1	MarR family winged helix-turn-helix transcriptional regulator	-
GTK42_RS10510 (2157243)	2157243..2158316	+	1074	WP_000954689.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
GTK42_RS10515 (2158374)	2158374..2158763	-	390	WP_000194089.1	RidA family protein	-
GTK42_RS10520 (2158934)	2158934..2159218	-	285	WP_000221347.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GTK42_RS10525 (2159208)	2159208..2159456	-	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GTK42_RS23425 (2159869)	2159869..2160222	-	354	WP_000418733.1	hypothetical protein	-
GTK42_RS10530 (2160225)	2160225..2160614	-	390	WP_001044696.1	hypothetical protein	-
GTK42_RS10535 (2161755)	2161755..2162087	+	333	WP_000253157.1	DUF1493 family protein	-
GTK42_RS10540 (2162360)	2162360..2163268	+	909	WP_077906523.1	hypothetical protein	-
GTK42_RS10545 (2163270)	2163270..2164050	-	781	Protein_2073	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2157243..2168701	11458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11074.86 Da
• Isoelectric Point: 10.7615

>T146206 WP_000221347.1 NZ_CP047424:c2159218-2158934 [Salmonella enterica subsp. enterica serovar Dessau]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKNQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Nucleotide

• Length: 285 bp

>T146206 NZ_CP062729:c4704352-4704038 [Escherichia coli O157:H7]
ATGCAATTTACGGTATACCGCAGTCGCAGTAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT146206 WP_000885424.1 NZ_CP047424:c2159456-2159208 [Salmonella enterica subsp. enterica serovar Dessau]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT146206 NZ_CP062729:c4704588-4704355 [Escherichia coli O157:H7]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Structures

Antitoxin

• AlphaFold DB: A0A5I0WPN5