Detailed information of TA system TA146205

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 826921..827735
• Replicon: chromosome
• Accession: NZ_CP047424
• Organism: Salmonella enterica subsp. enterica serovar Dessau strain KUFSE-SAL0043

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A8E5IG67
• Locus tag: GTK42_RS03955
• Protein ID: WP_000971651.1
• Coordinates: 826921..827448 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: GTK42_RS03960
• Protein ID: WP_000855694.1
• Coordinates: 827445..827735 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GTK42_RS03925 (823123)	823123..823521	+	399	Protein_773	cytoplasmic protein	-
GTK42_RS03930 (823732)	823732..823950	+	219	Protein_774	hypothetical protein	-
GTK42_RS03935 (824107)	824107..824775	+	669	WP_000445914.1	hypothetical protein	-
GTK42_RS03940 (824802)	824802..825296	+	495	WP_000424946.1	hypothetical protein	-
GTK42_RS03945 (825541)	825541..826197	-	657	WP_000420450.1	protein-serine/threonine phosphatase	-
GTK42_RS03950 (826430)	826430..826848	+	419	Protein_778	transposase	-
GTK42_RS03955 (826921)	826921..827448	-	528	WP_000971651.1	GNAT family N-acetyltransferase	Toxin
GTK42_RS03960 (827445)	827445..827735	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
GTK42_RS03965 (828329)	828329..828655	+	327	WP_000393295.1	hypothetical protein	-
GTK42_RS03970 (828928)	828928..829275	-	348	WP_001555786.1	DUF1493 family protein	-
GTK42_RS03975 (829260)	829260..829709	-	450	WP_000381609.1	hypothetical protein	-
GTK42_RS03980 (830141)	830141..830584	-	444	WP_000715095.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
GTK42_RS03985 (831041)	831041..831691	+	651	WP_001728903.1	type III secretion system transcriptional activator InvF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	826672..837004	10332
	-	flank	IS/Tn	-	-	826672..826848	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 18970.77 Da
• Isoelectric Point: 9.3905

>T146205 WP_000971651.1 NZ_CP047424:c827448-826921 [Salmonella enterica subsp. enterica serovar Dessau]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGGYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T146205 NZ_CP062729:4472623-4472883 [Escherichia coli O157:H7]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT146205 WP_000855694.1 NZ_CP047424:c827735-827445 [Salmonella enterica subsp. enterica serovar Dessau]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT146205 NZ_CP062729:4472344-4472604 [Escherichia coli O157:H7]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A3V8SJE7