Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2409751..2411291 Replicon chromosome
Accession NZ_CP047422
Organism Shewanella algae strain 18064-CSB-B-B

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GM320_RS11600 Protein ID WP_159352806.1
Coordinates 2409990..2411291 (+) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GM320_RS11595 Protein ID WP_071238726.1
Coordinates 2409751..2409987 (+) Length 79 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GM320_RS11575 2405205..2406437 - 1233 WP_159352804.1 hypothetical protein -
GM320_RS11580 2406563..2407360 - 798 WP_025888013.1 NYN domain-containing protein -
GM320_RS11585 2407392..2407766 - 375 WP_107110451.1 molecular chaperone DnaJ -
GM320_RS11590 2407790..2408827 - 1038 WP_159352805.1 IS630 family transposase -
GM320_RS11595 2409751..2409987 + 237 WP_071238726.1 helix-turn-helix domain-containing protein Antitoxin
GM320_RS11600 2409990..2411291 + 1302 WP_159352806.1 HipA domain-containing protein Toxin
GM320_RS11605 2411352..2412305 + 954 WP_159352807.1 sel1 repeat family protein -
GM320_RS11610 2412410..2413045 - 636 WP_115390024.1 peptide chain release factor H -
GM320_RS11615 2413045..2414208 - 1164 WP_115389739.1 RNA ligase RtcB family protein -
GM320_RS11620 2414598..2414945 - 348 WP_115389740.1 hypothetical protein -
GM320_RS11625 2415281..2415715 - 435 WP_115389741.1 HNH endonuclease -
GM320_RS11630 2415767..2416042 - 276 WP_201314543.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2407790..2408827 1037


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(146-387)

Antitoxin

(11-64)


Sequences


Toxin        


Download         Length: 434 a.a.        Molecular weight: 48513.36 Da        Isoelectric Point: 4.7440

>T146202 WP_159352806.1 NZ_CP047422:2409990-2411291 [Shewanella algae]
MSGAANLVLDMHLGDRIIGELSFDPATESFAVSYSQDWQQNGFPISPMIPLDGTGSSTQIAMFLGNLLPENRGLDYLIES
LGVSRGNTFALIRAIGLDTAGAVAFSLKGTELPQTAFREISDDEIILRLEDPELWPMEVWDGKPRLSVAGVQSKLNLFYN
GKQFGFGEGALSSTHILKFEKQRHLVINEFLTMRLAKAIAMNVANVEIRHFGRHKSLCVERFDRRYLPAEQRVLRRHIID
SCQALGFSVNKKYERNFGNGRDVRDIREGVSLPRLFALAEQCANPAAAKQDMLQWTLFNLLSGNADAHGKNYSFFMTPTG
MVPTPWYDLVCVALYEEFEQELAMAIDDEFDPDKIYAYQLAAFSEDIGLPRALVSNSLTRMATRISQEIDGVIAMLDGLD
KDEQAFVASYKAQLLARCERYLDIAPQINEMEL

Download         Length: 1302 bp

>T146202 NZ_CP062729:3752682-3753068 [Escherichia coli O157:H7]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8496.03 Da        Isoelectric Point: 9.0186

>AT146202 WP_071238726.1 NZ_CP047422:2409751-2409987 [Shewanella algae]
MVSPLTPHSLGALIKARRKEAALTLDVAAMLCGVTKKTFIRVEKGEDVYISTVFKILDGLGIHLLAQPKPDVDSTGWY

Download         Length: 237 bp

>AT146202 NZ_CP062729:3753058-3753387 [Escherichia coli O157:H7]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References